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Database: UniProt
Entry: A0A1S3G2X3_DIPOR
LinkDB: A0A1S3G2X3_DIPOR
Original site: A0A1S3G2X3_DIPOR 
ID   A0A1S3G2X3_DIPOR        Unreviewed;       407 AA.
AC   A0A1S3G2X3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 14 {ECO:0000313|RefSeq:XP_012883015.1};
GN   Name=Kcnj14 {ECO:0000313|RefSeq:XP_012883015.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha;
OC   Heteromyidae; Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012883015.1};
RN   [1] {ECO:0000313|RefSeq:XP_012883015.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012883015.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_012883015.1; XM_013027561.1.
DR   GeneID; 105994131; -.
DR   CTD; 3770; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000081671; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000081671};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_012883015.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     57     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     95    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    162       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      169    340       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      370    407       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    370    384       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE        148    148       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   407 AA;  44897 MW;  0E3F05A087C61AA1 CRC64;
     MGLAGALRRL SGAAEPGSGR GRFVKKDGHC NVRFVHLGGQ GARYLSDLFT TCVDVRWRWM
     CLLFSCSFLA SWLLFGLAFW LIASLHGDLA APPPPAPCFS QVASFLAAFL FALETQTSIG
     YGVRSVTEEC PAAVAAVVLQ CIAGCVLDAF VVGAVMAKMA KPKKRNETLV FSENAVVALR
     DRRLCLMWRV GNLRRSHLVE AHVRAQLLQP RVTPEGEYIP LDHQDVDVGF DGGTDRIFLV
     SPITIVHEID SSSPLYELGR AELARADFEL VVILEGMVEA TAMTTQCRSS YLPGELLWGH
     RFEPVLFQRG SQYEVDYRHF HRTYEVPGTP VCSAKELDER AEQASHSPKS SFPGSLAAFC
     YENELALSCC QEEEDEEETQ EEPGQEAEDR AASPRDISPT LQLTLPP
//
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