ID A0A1S3G3K7_DIPOR Unreviewed; 713 AA.
AC A0A1S3G3K7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Biotin--protein ligase {ECO:0000313|RefSeq:XP_012882874.1};
GN Name=Hlcs {ECO:0000313|RefSeq:XP_012882874.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012882874.1};
RN [1] {ECO:0000313|RefSeq:XP_012882874.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012882874.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC {ECO:0000256|ARBA:ARBA00009934}.
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DR RefSeq; XP_012882874.1; XM_013027420.1.
DR AlphaFoldDB; A0A1S3G3K7; -.
DR STRING; 10020.ENSDORP00000024420; -.
DR GeneID; 105994008; -.
DR KEGG; dord:105994008; -.
DR CTD; 3141; -.
DR InParanoid; A0A1S3G3K7; -.
DR OrthoDB; 317678at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd16442; BPL; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR InterPro; IPR003142; BPL_C.
DR InterPro; IPR004143; BPL_LPL_catalytic.
DR NCBIfam; TIGR00121; birA_ligase; 1.
DR PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR Pfam; PF02237; BPL_C; 1.
DR Pfam; PF03099; BPL_LplA_LipB; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|RefSeq:XP_012882874.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 440..638
FT /note="BPL/LPL catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51733"
FT REGION 31..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 79110 MW; 87A2D1B5BC78DF65 CRC64;
MEDRLQMDNG LIPQKIVSVH LQDSTLKELK DQAARGQVQS LKLAARPSPE PKPVQHADRD
EPRAPGQDSC KQRTDGEGEP EEHSHLHLFS CHECLELENS TIESVKFASA ENIPDLPYDH
SSGLEAVTDE LCPKREESRV NMVGKAPNIL VYVGPGTQDT LGRLEQVRSV LADCVDADSY
TIYHLPEDSG LRDPWADNCI LLVIAALEPI PKDLYQKFMA YLSQGGKVLA LSSSFTFGGF
QVTGEGMLRK TVQDLVFCKA DRSEVRLSVL SSGRFYKAGP REQLSPAGLH GHLDTEDKDR
TILQVPFGSC GGEAVLCQVH LELPPSSPTV QTQEDFNLLK SSNMKRYEVL REILTTLGIS
CDVRQVPALT PVSLLLATEE IRDPLMQWLG AHVDPKGVIK SSKLSLKFVS SCASEVEVTP
SSIPVITDTE DFSSEHFNLD IYRQNLQTKQ LGKVILFAEV TPTTMNLLDG LMFEMPQEMG
LIAIAVRQTQ GKGRGPNAWL SPVGCALSTL LISIPLRSQL GQRIPFVQHL MSLAVVEAVR
STPKYQDINL RVKWPNDIYY SDLMKIGGVL VNSTLLGETF YILIGFGFNV TNSNPTICIN
DLITEHNKQH KTALKPFRAD CLIARAVTML EKLVHTFQDE GPQSILPLYY KYWLHSGQQV
RLGSTEGPQV SIVGLDDSGF LQVHQEDGRI VTVHPDGNSF DMLRNLIVPK QRW
//