ID A0A1S3G504_DIPOR Unreviewed; 1183 AA.
AC A0A1S3G504;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nuclear receptor coactivator 2 {ECO:0000313|RefSeq:XP_012883903.1};
GN Name=Ncoa2 {ECO:0000313|RefSeq:XP_012883903.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012883903.1};
RN [1] {ECO:0000313|RefSeq:XP_012883903.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012883903.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR RefSeq; XP_012883903.1; XM_013028449.1.
DR AlphaFoldDB; A0A1S3G504; -.
DR STRING; 10020.ENSDORP00000010246; -.
DR GeneID; 105994804; -.
DR KEGG; dord:105994804; -.
DR CTD; 10499; -.
DR InParanoid; A0A1S3G504; -.
DR OrthoDB; 4230728at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR SMART; SM01151; DUF1518; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|RefSeq:XP_012883903.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1000..1057
FT /note="DUF1518"
FT /evidence="ECO:0000259|SMART:SM01151"
FT REGION 181..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 127452 MW; 17FBBD52243F2FD1 CRC64;
MRAAMKPGWE DLVRRCIQKF HAQHEGESVS YAKRHHHEVL RQGLAFSQIY RFSLSDGTLV
AAQTKSKLIR SQTTNEPQLV ISLHMLHREQ NVCVMNPDLT APAMGKPLNP ISSSSPAHQA
MCSGNPGQDM TLSSNINFPI NGPKEQMGMP MGRFGGSGGM NHVSGMQATT PQGSNYALKM
NSPSQSSPGM NPGQHTSMLS PRHRMSPGVA GSPRIPPSQF SPAGSLHSPV GVCSSTGNSH
SYTNSSLNAL QALSEGHGVS LGSSLASPDL KMGNLQNSPV NMNPPPLSKM GSLDSKDCFG
LYGEPSEGTT GQAENSCHPG EQKETSDSSM PQAVSADRAE GQNRLHDSKG QTKLLQLLTT
KSDQMEPSPL PSSLSDTNKD STGSLSGPGS THGTSLKEKH KILHRLLQDS SSPVDLAKLT
AEATGKELSQ ETSSTAPGSE VTIKQEPVSP KKKENALLRY LLDKDDTKDI GLPEITPKLE
RLDSKTDPAS NTKLIAMKTE KEEMSFEPSD QPGSELDNLE EILDDLQNSQ LPQLFPDTRP
GAPAGSVDKQ AIINDLMQLT AENSPVTPVG AQKTALRISQ STFNNPRPGQ LGRLLPNQNL
PLDITLQSPT GAGPFPPIRN NSPYSVIPQP GMMGNQGMIG NQGNLGNSST ASFGLHAGMI
GSNASRPTMP SGEWAPQSSP VRVTCAATTS AMNRPIQGGM IRNPTASIPM RPNNQPGQRQ
MLQSQVMNIG PSELEMNMGG AQYSQQAPPN QTAPWPESIL PIDQASFANQ NRQPFGSSPD
DLLCPHPASE SPSDEGALLD QLYLALRNFD GLEEIDRALG IPELVSQSQA VDPEQFSSQD
SNIMLEQKAP VFPQQYASQA QMAQGSYTPM QDANFHTMGQ RPSYAALRMQ PRPGLRPTGL
VQNQPNQLRL QLQHRLQAQQ NRQPLMNQIS NVSNVNLTLR PGVPTQAPIN AQMLAQRQRE
ILNQHLRQRQ MHQQQQVQQR TLMMRGQGLN MTPSMVAPSG IPATMSNPRI PQANAQQFPF
PPNYGISQQP DPGFTGATTP QSPLMSPRMA HTQSPMMQQS QANPAYQAPS DMNGWAQGNM
GGNSMFSQQS PPHFGQQANT SMYNNNMNIN VSMATNTGGM SNMNQMTGQI SMTSVTSVPT
SGLSSMGPEQ VNDPALRGGS LFPNQLPGMD MIKQEGDASR KYC
//
