ID A0A1S3GA24_DIPOR Unreviewed; 586 AA.
AC A0A1S3GA24;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Parathyroid hormone/parathyroid hormone-related peptide receptor {ECO:0000256|ARBA:ARBA00020798};
DE AltName: Full=PTH/PTHrP type I receptor {ECO:0000256|ARBA:ARBA00030334};
DE AltName: Full=Parathyroid hormone 1 receptor {ECO:0000256|ARBA:ARBA00032662};
GN Name=Pth1r {ECO:0000313|RefSeq:XP_012885678.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012885678.1};
RN [1] {ECO:0000313|RefSeq:XP_012885678.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012885678.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR RefSeq; XP_012885678.1; XM_013030224.1.
DR AlphaFoldDB; A0A1S3GA24; -.
DR STRING; 10020.ENSDORP00000014682; -.
DR GeneID; 105996209; -.
DR KEGG; dord:105996209; -.
DR CTD; 5745; -.
DR InParanoid; A0A1S3GA24; -.
DR OrthoDB; 5397182at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004991; F:parathyroid hormone receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR002170; GPCR_2_parathyroid_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF27; PARATHYROID HORMONE_PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR00393; PTRHORMONER.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012885678.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..586
FT /note="Parathyroid hormone/parathyroid hormone-related
FT peptide receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010160907"
FT TRANSMEM 183..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..168
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 181..457
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 66077 MW; 379CF0CFA88AD515 CRC64;
MMLVVMVLVE TEMMMMVVAV DSDDVFTKEE QIFLLHRAQA QCDKLLKEVL RRAANIMESD
KGWTAASTSG KPRKEKAPGR LYPESKENKE VVPGSRRRGR TCLPEWDNIV CWPLGAPGEV
VAVPCPDYIY DFNHKGHAYR RCDRNGSWEV VPGHNRTWAN YSECLKFMTN ETREREVFDR
LGMIYTVGYS MSLASLTVAV LILAYFRRLH CTRNYIHMHM FLSFMLRAAS IFVKDAVLYS
GFTLDEAERL TEEELHLIAQ VPPPPAAAAV GYAGCRVAVT FFLYFLATNY YWILVEGLYL
HSLIFMAFFS EKKYLWGFTI FGWGVPAVFV AVWVGVRATL ANTGCWDLSS GHKKWIIQVP
ILASVVLNFI LFINIIRVLA TKLRETNAGR CDTRQQYRKL LKSTLVLMPL FGVHYTVFMA
LPYTEVSGTL WQIQMHYEML FNSFQGFFVA IIYCFCNGEV QAEIKKSWSR WTLALDFKRK
ARSGSSSYSY GPMVSHTSVT NVGPRAGLSL PLSPRLLPAA TTNGHSQLPG QAKPGPPALE
TEPTPVTMTA PKDDGFLNGS CSGLDGEASE PTQTPPLLPE EWETVM
//
