ID A0A1S3GAB3_DIPOR Unreviewed; 573 AA.
AC A0A1S3GAB3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Fibrinogen alpha chain {ECO:0000256|ARBA:ARBA00017850};
GN Name=Fga {ECO:0000313|RefSeq:XP_012885189.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012885189.1};
RN [1] {ECO:0000313|RefSeq:XP_012885189.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012885189.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_012885189.1; XM_013029735.1.
DR AlphaFoldDB; A0A1S3GAB3; -.
DR STRING; 10020.ENSDORP00000009432; -.
DR GeneID; 105995857; -.
DR KEGG; dord:105995857; -.
DR CTD; 2243; -.
DR InParanoid; A0A1S3GAB3; -.
DR OrthoDB; 3134470at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR Gene3D; 1.20.5.50; -; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR021996; Fibrinogen_aC.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF12160; Fibrinogen_aC; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..573
FT /note="Fibrinogen alpha chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010178786"
FT DOMAIN 48..192
FT /note="Fibrinogen alpha/beta/gamma chain coiled coil"
FT /evidence="ECO:0000259|SMART:SM01212"
FT REGION 261..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 61563 MW; 67BA0397DE672129 CRC64;
MFTVRITCLV LSVASTVWTT DTGEGDFIEQ GGQGRGPRIM EKQQSACKET DWPFCSDDDW
GPKCPSGCRM KGLIDEANQD FTNRINKLKN SLFDFQKNNK DSSSLTRNIM ELLRGDLAKA
NNYDNTYNQV SEDLRSRIEI LKSKVMEKVQ HIQLLQNNVR AQLIDMKRLE VEVDIKIRSC
KGSCSRALSR ELRLSDYEDQ QRQLEQVMAK DLLPPRESQY FPIIKMRPMP DLVPGSFKSQ
LQTAPPEWKA LTEMQQMRME LEGPGREGGP GRAGSPRGDA VGYVEDTGPV TESPRHPRPG
GAGHWSSGPG TDGSRNPGTT GAGGPGRWQQ PGDTGSSPSG SWNTGGAGSF RPAGSSPDWG
EFTEESGGPA TRKEQPAGRL PATKADKELL IGREKGAPSA GGPAFARRAC SKTVTKTVIG
PDGRKEVTKE VVTSEDGSDC GGDVADLGLQ GFGSRGSLDE LARRHPDVSS FFGTGALEPF
STFKEPGGGA DGDIFADLEH GGGGSQAEPW SGGTATHRKL VTSSSSSSST ISRGGSASGT
KNYKMADEAA GEEARSTKRG RARPRPARGI HLP
//