GenomeNet

Database: UniProt
Entry: A0A1S3GAZ6_DIPOR
LinkDB: A0A1S3GAZ6_DIPOR
Original site: A0A1S3GAZ6_DIPOR 
ID   A0A1S3GAZ6_DIPOR        Unreviewed;      1011 AA.
AC   A0A1S3GAZ6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE            Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE            EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
GN   Name=Dgkz {ECO:0000313|RefSeq:XP_012885419.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012885419.1};
RN   [1] {ECO:0000313|RefSeq:XP_012885419.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012885419.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-
CC         octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00023371};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328;
CC         Evidence={ECO:0000256|ARBA:ARBA00023371};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
CC         + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC         3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091,
CC         ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00023400};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40324;
CC         Evidence={ECO:0000256|ARBA:ARBA00023400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC         phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:456216; EC=2.7.1.107;
CC         Evidence={ECO:0000256|ARBA:ARBA00023411};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10273;
CC         Evidence={ECO:0000256|ARBA:ARBA00023411};
CC   -!- PATHWAY: Lipid metabolism; glycerolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00005175}.
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC       {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012885419.1; XM_013029965.1.
DR   AlphaFoldDB; A0A1S3GAZ6; -.
DR   STRING; 10020.ENSDORP00000007862; -.
DR   GeneID; 105996027; -.
DR   KEGG; dord:105996027; -.
DR   CTD; 8525; -.
DR   InParanoid; A0A1S3GAZ6; -.
DR   OrthoDB; 4642163at2759; -.
DR   UniPathway; UPA00230; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd20895; C1_DGKzeta_rpt2; 1.
DR   Gene3D; 2.60.200.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR047484; C1_DGKzeta_rpt2.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR   PANTHER; PTHR11255:SF43; DIACYLGLYCEROL KINASE ZETA; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50146; DAGK; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   ATP-binding {ECO:0000256|RuleBase:RU361128};
KW   Kinase {ECO:0000256|RuleBase:RU361128, ECO:0000313|RefSeq:XP_012885419.1};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|RuleBase:RU361128};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          374..508
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   REPEAT          905..928
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          940..972
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..352
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  112650 MW;  27B44F38F39CD12A CRC64;
     METFFRRHFQ RKASGPGEGQ RRPSSVGLPT GKARRRSPAG QASSSLAQRR RSSAQLQGCL
     PSCGVGIRGA SRRRSSTVPP ACNPRFSVET GPVRRGAQLL GAPLLLAGLV GMEEEEERVD
     VTNEASGAAQ PSTRTPGPSP PRGPRPLLPM PRCLRRASSH LLPADVVCGQ TLCGLRGHYR
     RLSQQRPSGR RASGSTLGST IPTHRRPLSR RRQVALRRKS AGPQAWSALL INFRCKPSFR
     ESGSRNVREP TFVRHHWVHR RRQDGKCRHC GKGFQQKFAF HSKEIVAISC SWCKQAYHSK
     VSCFMLQQIE EPCSLGVHAA VVIPPTWILR ARRPQNTLKA SKKKKRTSFK RKSSKKGPEE
     GRWRPFIIRP TPSPLMKPLL VFVNPKSGGN QGAKIIQSFL WYLNPRQVFD LSQGGPKEAL
     EMYRKVHNLR ILACGGDGTV GWILSTLDQL RLKPPPPVAI LPLGTGNDLA RTLNWGGGYT
     DEPVSKILSH VEEGNVVQLD RWDLRAEPNP EAGPEERDEG ATDRLPLDVF NNYFSLGFDA
     HVTLEFHESR EANPEKFNSR FRNKMFYAGT AFSDFLMGSS KDLAKHIRVV CDGMDLTPKI
     QDLKPQCIVF LNIPRYCAGT MPWGHPGEHH DFEPQRHDDG YLEVIGFTMT SLAALQVGGH
     GERLTQCREV LLTTAKAIPV QVDGEPCKLT ASRIRIALRN QATMVQKAKR RSTAPLHSDQ
     QPVPEQLRIQ VSRVSMHDYE ALHYDKEQLK EASVPLGTVV VPGDSDLELC RAHIDRLQQE
     PDGAGAKSPT CQKLSPKWCF LDATTASRFY RIDRAQEHLN YVTEIAQDEI YILDPELLGA
     SARPDLPTPT SPLPASPCSP TPRSLQGDAV PPQGEELIEA AKRNDFCKLQ ELHRAGGDLM
     HRDQQSRTLL HHAVSTGSKE VVRYLLDHAP QEILDAVEEN GETCLHQAAA LGQRTICHYI
     VEAGASLMKT DQQGDTPRQR AEKAQDTELA AYLENRQHYQ MIQREDQETA V
//
DBGET integrated database retrieval system