ID A0A1S3GCP0_DIPOR Unreviewed; 1364 AA.
AC A0A1S3GCP0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Vascular endothelial growth factor receptor 3 {ECO:0000256|ARBA:ARBA00022258};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=Flt4 {ECO:0000313|RefSeq:XP_012886470.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012886470.1};
RN [1] {ECO:0000313|RefSeq:XP_012886470.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012886470.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. CSF-1/PDGF receptor subfamily.
CC {ECO:0000256|RuleBase:RU000311}.
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DR RefSeq; XP_012886470.1; XM_013031016.1.
DR STRING; 10020.ENSDORP00000012111; -.
DR GeneID; 105996799; -.
DR KEGG; dord:105996799; -.
DR CTD; 2324; -.
DR InParanoid; A0A1S3GCP0; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IEA:UniProt.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05862; IgI_VEGFR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR InterPro; IPR041348; VEGFR-2_TMD.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF49; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF21339; VEGFR-1-like_Ig-like; 1.
DR Pfam; PF17988; VEGFR-2_TMD; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR PRINTS; PR01835; VEGFRECEPTR3.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 5.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE 3: Inferred from homology;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU000311}; Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000311};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000311};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1364
FT /note="Vascular endothelial growth factor receptor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010175256"
FT TRANSMEM 776..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 219..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..415
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 422..552
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 555..671
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 678..764
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 845..1172
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1287..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1036
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 879
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1041
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 1054
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 1364 AA; 152781 MW; 248B6B9B300E5138 CRC64;
MPRLAAPCLR LWLCLGFLDG LVSGYSMTPP TLNITEDQYI IDTSDSLSIS CSGQHPLEWA
WPGAQEAPAT AEKDSEDTGV VQDCEGTDAR PYCKVLLLTE AHANNTGSYR CYYKYIKARI
EGTTAASTYV FVRDFEQPFI SKPDTLLVNR KDSMWVPCLV SIPGLNVTLR SQNSVLRPDG
QEVVWDDRRG MQVPTPLLRD ALYLQCETSW GGQDFLSNPF LVHITGNELY DIQLFPKKSL
ELLVGEKLVL NCTVWAEFNS GVTFDWDYPG KQEERGKWVP ERRAQQTHTE LSSILTIYNV
SQHDLGPYVC EANNGIQRFR ESTEVIVHEK PFISVEWLKG PVVEATAGDE LVKLPVKLSA
YPPPEFQWYK DKKAVAGRHS PHALVFKEVT EANAGVYTLA LWNSAAGLQR NISLELVVNV
PPHIHEKEAS SPSIYSRHSR QTLTCTAYGV PPPLSIQWHW RPWTPCKTFA QRSLRRRQQR
DRMPQCRDWR QVTMQDAVNP IESLDTWTEF VEGKNKTVSK LVIQDANVSA MYKCVVFNKV
GQDERLIYFY VTTIPDGFSI ESEPSEEPLE GQSVRLSCRA DNYTYQHLRW YRLNLSTLHD
AHGNPLLLDC KNVHLFATPL DANLEEATPG TRHATLSLNI PRVAPEHEGD YVCEVQDRRS
QDKHCHKKYL SVQALEAPRL TQNLTDLLVN VSDSLEMRCA VAGSHVPSIV WYKDERLLEE
ESGIDLADSN QKLSIQRVRE EDAGHYLCSV CNAKGCVNSS ASVAVEGSED KGSMEIIILI
GTGVIAVFFW VLLLLIFCNM RRPAHADIKT GYLSIIMDPG EVPLEEQCEY LSYDTSQWEF
PRERLHLGRV LGHGAFGKVV EASAFGISKG SSCDTVAVKM LKEGATASEH RALMSELKIL
IHIGNHLNVV NLLGACTKPS GPLMVIVEFC KYGNLSNFLR AKRDTFSPYA EKSPEQRRRF
HAMVEGAKID GRRAGSDRAL FARLLIGKGG AGRVPPVQEV EDLWLSPLTM EDLVCYSFQV
ARGMEFLASR KCIHRDLAAR NILLSESDIV KICDFGLARD IYKDPDYVRK GSARLPLKWM
APESIFDKVY TTQSDVWSFG VLLWEIFSLG ASPYPGVQIN EEFCQRLKEG TRMRAPELAT
PAIRRIMLSC WSGDPKARPA FSELVEILGD LLQGGGLQEE EQDCMARCGS QSSEEGGFLQ
TSTTALHVAE AEAEDSPPSM HRHSLAARYY NCVSFPGCLA RGAQTEGSSR MKTFEEFPMT
PTTYKASVDN QTDSGMVLAS EEFERIESRH RQEDSFSSCK GPGQDVDDSR AHPDLQGRRR
RTNRGAGQAG QGFYNTEYGK LSQPCEEADH TPSGGAPFFT DTGY
//
