ID A0A1S3GEU2_DIPOR Unreviewed; 718 AA.
AC A0A1S3GEU2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=Slc28a3 {ECO:0000313|RefSeq:XP_012886512.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012886512.1};
RN [1] {ECO:0000313|RefSeq:XP_012886512.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012886512.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
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DR RefSeq; XP_012886512.1; XM_013031058.1.
DR STRING; 10020.ENSDORP00000007513; -.
DR GeneID; 105996827; -.
DR KEGG; dord:105996827; -.
DR CTD; 64078; -.
DR InParanoid; A0A1S3GEU2; -.
DR OrthoDB; 1333063at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 256..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 507..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 582..606
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 233..304
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 312..410
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 415..637
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 79698 MW; D655770FA812B78D CRC64;
MLSEVGGPPG QTQERIQSPA NIRRNMEMRS PATARTSRTE GYSNTGFQDE SILENQNASG
NNSIRSRAVQ SREQGNTEQG EEAQVTIEQD ALRNKEDTEE DQDVIPKGYL EKKYATVCDF
CRKHKTILRY IIWGTLLTGF LALVITACVL NFHRALPLFV ITVAVIFFVV WDHLMARYEH
RIDELLSPGR RLLDSHWFWL KWVIWSLLIL GVIFWLILDT AKLGKQQLVS FGGLITYIIL
LFLFSKHPTR VHWRPVFWGI GLQFLLGLLI LRTKPGFIAF DWLGRQVQTF LGYTDAGAIF
VFGEKYTDHF FAFKILPIVV FFSTVMSMLY YLGFMQWIVR KVGWVMLVTL GSSPIESVVA
AGNIFVGQTE SPLLVRPYLP HVTKSELHAV MTAGFATIAG SVLGAYISFG VSSTHLLTAS
VMSAPASLAV AKLFWPETEK PKITLKNAMK MENGDSRNLL EAATQGASSS IPLVANIAVN
LIAFLALLSF MNSALSWFGN MFDYPQLSFE LICSYLFMPF SFVMGVDWQD SFMLAKLLGY
KTFFNEFVAY EHLSKLINLR KAAGPKFVDG VQQYMSIRSE TIATYALCXF ANMGSLGIVI
GGLTSIAPCR KRDIASGAVR ALIAGTIACF MTACIAGMLS DTPVDINCHH ILESTFNSSF
PSNMTDVVSC CQSLLHSTIA KGPGEIIPGG NHSLSSLKGC CTLVNPSTLN CSWIPNTF
//
