ID A0A1S3GEZ4_DIPOR Unreviewed; 905 AA.
AC A0A1S3GEZ4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Integrin alpha-IIb {ECO:0000313|RefSeq:XP_012887391.1};
GN Name=Itga2b {ECO:0000313|RefSeq:XP_012887391.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887391.1};
RN [1] {ECO:0000313|RefSeq:XP_012887391.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887391.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_012887391.1; XM_013031937.1.
DR AlphaFoldDB; A0A1S3GEZ4; -.
DR STRING; 10020.ENSDORP00000005405; -.
DR GeneID; 105997503; -.
DR KEGG; dord:105997503; -.
DR CTD; 3674; -.
DR InParanoid; A0A1S3GEZ4; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 32..905
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5010003513"
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 174..239
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 242..300
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 303..364
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 349..500
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 501..641
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 647..854
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 905 AA; 98958 MW; B81A46C9317ED117 CRC64;
MARALYPLNA LWFLECALLF LGPSATPPAW ALNLDPVQFT FYSGPNGSHF GFSVDFHKDN
HGSSPFVVAT VQGGVWAGEL VLGAPGGYFF LGLLVRAPIA SIISSYRPGT LLWHVPNQRF
TYDSSNIDYF DGYRGYSVAV GEFDGDPSTT EYIFGAPTWS WTLGAVEILD KYYQTLHRLH
GEQMASYFGY SVAVTDVNGD ERHDLLVGAP LYMESRADRK LAEVGRVYLF LQPRGPHALG
PPSLLLTGTQ LYGRFGSTIA PLGDLNRDGY NDVAVAAPYG GPDGRGQVLV FLGQSEGLSA
RPSQVLDSPF RTGSGFGFSL RGSVDIDDNG YPDLLVGAYG VSKVAVYRAQ PVVMATVQLL
VQDSLNPAVK NCVLQPAKTP VSCFTIQMCV GATGHNIPQK LYLNAELQLD RQKPRQGRRV
LLLDSQQSGL TLRLDLSRSQ SPTCHNTTAF LQDEADFRDK LSPIVLSLNV SLPTQETGVA
PAVVLHGDTH VQEQTRIILD CGEDDLCVPH LQLNATMKGS PLIIGADNVL ELQMDAANEG
EGAYEAELAV HLPPGAHYMR ALSNLQGLER LICNQKKENE SRVVLCELGN PMKNNAQIRI
TMLVSVGNLE EAGESVSFQL QVRSKNSQNP NSKAVLLDVP VRADARVELR GNSFPASLVV
AAEEGDKKQN GLDSLVLRVE HTYELHNDGP GTVNGLHLSI HLPGQSQPSD LLYFLDIQTQ
GGLQCSPQPS PNPLKLEWRL PTPSPSSTLP VHHKRERREA VLPAPKPHGE QETVLVSCDS
APCTAVQCEL QEMARGQRAM VTVLAFLQLP SFRARPLEQF VLQSHGWFNV SSFPYAVPAL
SLPSGEALVQ TQLLRALEER AIPIWWMLVG VLGGLLLLTL LVLLMWKVGF FKRNRPPLEE
DEEEE
//
