ID A0A1S3GFA5_DIPOR Unreviewed; 366 AA.
AC A0A1S3GFA5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-27 alpha chain-like {ECO:0000313|RefSeq:XP_012886662.1};
GN Name=LOC105996958 {ECO:0000313|RefSeq:XP_012886662.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012886662.1};
RN [1] {ECO:0000313|RefSeq:XP_012886662.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012886662.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR RefSeq; XP_012886662.1; XM_013031208.1.
DR AlphaFoldDB; A0A1S3GFA5; -.
DR STRING; 10020.ENSDORP00000006549; -.
DR GeneID; 105996958; -.
DR KEGG; dord:105996958; -.
DR InParanoid; A0A1S3GFA5; -.
DR OrthoDB; 3840485at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022451};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..366
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010266322"
FT DOMAIN 209..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 366 AA; 41706 MW; ED9DCCBBFDAFFF17 CRC64;
MGIMPIFSLL LLLWGGLAPK QTWAGFHSLK YLDTAVSRPG RADTRFITIG YVDDTPFARY
DSEAPSPKME PRAPWVEPAG TQHWEQQTQY CKANAQTFRI QLRTLLGYYN QSGDGSHTYQ
RICGCDVGPD GRFLRGYRTD AYDGEDFISL NEDLNTWTAS DTVAQITRRK WEATGEAEQE
RAYLEKECVK RLLRYLENGK EALKRADPPE TNVTHHPTSD HEVTLKCWAR GFYPAEITLI
WQRDGEDQTQ EMELVETRPA GDGTFQKWAA IVVPSGEEQR YTCHVQHEGL PEPLSLTWEL
PPSTNSPSQK LSLSWFSLDV WWLLQCGGRK QVLTVSRTLL HFSWEGVLKS CLCGTDTRLV
HVSLVM
//
