ID A0A1S3GFS5_DIPOR Unreviewed; 1535 AA.
AC A0A1S3GFS5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Brain-specific angiogenesis inhibitor 3 {ECO:0000313|RefSeq:XP_012887718.1};
GN Name=Adgrb3 {ECO:0000313|RefSeq:XP_012887718.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887718.1};
RN [1] {ECO:0000313|RefSeq:XP_012887718.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887718.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_012887718.1; XM_013032264.1.
DR STRING; 10020.ENSDORP00000013721; -.
DR GeneID; 105997745; -.
DR KEGG; dord:105997745; -.
DR CTD; 577; -.
DR InParanoid; A0A1S3GFS5; -.
DR OrthoDB; 4181250at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF40; ADHESION G PROTEIN-COUPLED RECEPTOR B3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 880..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 502..572
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 878..1157
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1535 AA; 171194 MW; BD2AC7A140304946 CRC64;
MKAVGELLIS IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE
NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCDSKNAFVF
VQYDKNFIQI RRVFPAEFPG SQRKGDHDQK SFFEFLVLNK VSPSQFGCQV LCTWLESCLK
SENGRAESCG AMYTKCSCPQ HLGELGGDDQ ASVVLLSNVV LPLNEQTEGC LTQELQTTQM
CNLTREARRP PKEEFGMMGD HTIKSQRPRS VHEKRVPQEP ADAAKFMAQT GESGVEDWSP
WSPCSVTCGQ GSQVRTRTCV SPFGTHCSGP LRESRVCNNT ALCPVHGVWE EWSPWSLCSF
TCGRGQRTRT RACSPPQYGG RPCEGPETHH KPCNIALCPV DGQWQEWSSW SQCSVTCSNG
TQQRSRQCTA AAHGGSECRG PWAESRECYN PECTANGQWN QWGHWSGCSR SCDGGWERRV
RTCQGAAVTG QQCDGAGEEV RRCSEQRCPA PYEICPEDYL ISMVWRRTPA GDLAFNQCPL
NATGTTSRRC SLSLQGVAFW EQPSFARCIS NDYRLLQHSI KEHLAKGQRT LAGDGMSQVT
KTLLDLTQRK NFYAGDLLMS VEILRNVTDT FKRASYVPGS DGVQNFFQIV SNLLDEENKE
KWEDAQQIYP GSIELMQVIE DFIHVVGVGM MDFQNSYLMT GNVVASIQKL PAASVLTDIN
FPMKGRKGMV DWARNSEDRV LIPKSIFSPV SSKELDESSV FVLGAVLYKN LDLILPTLRN
YTVVNSKIIV VTIRPEPKAT DSFLEIELAH LANGTLNPYC VLWDDSKTNQ SSGAWSTRGC
RTVLTDASHT KCLCDRLSTF AILAQQPREI IMESSGTPSV TLIVGSGLSC LALITLAVVY
AALWRYIRSE RSIILINFCL SIISSNILIL VGQTQTHNKS ICTTTTAFLH FFFLASFCWV
LTEAWQSYMA VTGKIRTRLI RKRFLCLGWG KDSCHEDMAL KGLGIVRGQP SEVVREELCW
LSLEGGLLYA FVGPAAAVVL VNMVIGILVF NKLVSRDGIL DKKLKHRASQ MSEPHSGLTL
RCAKCGVVST TALSATTASN AMASLWSSCV VLPLLALTWM SAVLAMTDKR SILFQILFAV
FDSLQGFVIV MVHCILRREV QDAFRCRLRN CQDPINADSS SSFPNGHAQI MTDFEKDVDI
ACRSVLHKDL GPCRTATITG TLSRISLNDD EEDKGAAPEG LSYSTLPGNV LSKVVLQQPA
PLHVPMGRGE LGAPCLPEGG ELRRTVYLCT DEDLRGAERD LGHPQDRVLD SDYIVMPRGS
VSAPPPTKDE SKMNLGMDTL PHERLLHYKV SPDFSMAPPV MEQFGGNLDQ LNAPILDPHL
APREHMQSMA FEPRTAVKNF MAAELDEGAG LSRSETGSTI SMSSLERRKS RYSDLDFEKV
MHTRKRHMEL FQELNQKFQT LDRFRDIPNT SSMEAPVPSK SPWDTFQAPS EYQHYTTINV
LDTETKDALE LRPAEWEKCL SLPLDVQEGD FQTEV
//
