ID A0A1S3GGA0_DIPOR Unreviewed; 505 AA.
AC A0A1S3GGA0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Parathyroid hormone 2 receptor {ECO:0000313|RefSeq:XP_012887037.1};
GN Name=Pth2r {ECO:0000313|RefSeq:XP_012887037.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887037.1};
RN [1] {ECO:0000313|RefSeq:XP_012887037.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887037.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR RefSeq; XP_012887037.1; XM_013031583.1.
DR AlphaFoldDB; A0A1S3GGA0; -.
DR STRING; 10020.ENSDORP00000005378; -.
DR GeneID; 105997208; -.
DR KEGG; dord:105997208; -.
DR CTD; 5746; -.
DR InParanoid; A0A1S3GGA0; -.
DR OrthoDB; 5397182at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF7; PARATHYROID HORMONE 2 RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012887037.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..84
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 101..373
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 505 AA; 57269 MW; 89ACF7F329A1B49C CRC64;
MKAKVQCELN ITAQHQEGEG NCFPEWDGLI CWPRGTVGKM SAVPCPPYIY DFNHKGVALR
HCTPNGTWDF MHSSNKTWAN YSDCFLQPDI NVGKQEFFES LYILYTIGYS ISFGSLAVAI
LTIGYFRRLH CTRNYIHLHL FVSFMLRAVS IFVKDRVAQA HLGVEELQSL VMQGDLQNPM
GAPAVDKSQY IGCKIAVVMF IYFLATNYYW ILVEGLYLHN LIFVSFFSDT KYLWGFILIG
WGFPAAFVVA WAVARATLAD ARCWELSAGD RWIYQAPILA AIGMNFILFL NTVRVLATKI
WETNAVGHDM RKQYRKLAKS TLVLVLVFGV HYIVFICQPH SFTGLWWEIR MHCELFFNSF
QGFFVSIIYC YCNGEVQGEV KKMWSRWNLS INWKRTPSCG GQRYGSVLTT VTHSSVSQSH
MGASTRMVLI SGKQAKTASI LPESHMTLPG YVWSGSDQDC SPLSIQEMKE GEGRQGGDIP
VEASSRHLEF ILDSESCKRE AEDAI
//