ID A0A1S3GGH3_DIPOR Unreviewed; 531 AA.
AC A0A1S3GGH3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Keratin, type II cytoskeletal 74 isoform X1 {ECO:0000313|RefSeq:XP_012887906.1};
GN Name=Krt74 {ECO:0000313|RefSeq:XP_012887906.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887906.1};
RN [1] {ECO:0000313|RefSeq:XP_012887906.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887906.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_012887906.1; XM_013032452.1.
DR AlphaFoldDB; A0A1S3GGH3; -.
DR STRING; 10020.ENSDORP00000012391; -.
DR GeneID; 105997901; -.
DR KEGG; dord:105997901; -.
DR CTD; 121391; -.
DR InParanoid; A0A1S3GGH3; -.
DR OMA; IQRIRCD; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:1990254; F:keratin filament binding; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF5; KERATIN, TYPE II CYTOSKELETAL 74; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 140..453
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 482..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..278
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 351..431
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 516..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 58173 MW; EECFF9747CAEB668 CRC64;
MSRQLNFRPG GDKGSFSVLS AVVPRKALGS MASYRASGQG VGASFGSRSL YSLVGNRHIS
FNTAGSGIRA GAPSFGHGSG YGGGRASGFA GSMFGSVALG PACPSVCPPG GIHQVTVNKS
LLAPLNVELD PKIQKVRAQE REQIKALNDK FASFIDKVRF LEQQNQVLET KWELLQQLDL
NNCRKSLEPI YEGHISSLRK QLETLSGDRV RLDSELRSMR DVVEDYKKKY EVEINRRTAA
ENEFVVLKKD ADAAYTVKVE LQAKVDSLEK DIKFLKCLYD AEIAQIQTHA SETSVILSMD
NNRDLDLDSI ITEVRAHYED IALKSKAEAE ALYQTKIQEL QLAAGRHGDD LKHTRSEMSE
LNRLIQRIRC DITNVKKQCS NLEMVIADAE QRGDSALKDA RDKLDELEGA LHQAKGELAR
LMREYQELMS LKLSLDMEIA TYRKLLEGEE CRMSGENPSS VSISVISSNS YGSYGYNPSS
ASADLGAGSV AGSPSSPRSG QIKSRGGRGG DHQESQEKSV PASMPARKTT R
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