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Database: UniProt
Entry: A0A1S3GH74_DIPOR
LinkDB: A0A1S3GH74_DIPOR
Original site: A0A1S3GH74_DIPOR 
ID   A0A1S3GH74_DIPOR        Unreviewed;       559 AA.
AC   A0A1S3GH74;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
GN   Name=Pou2f2 {ECO:0000313|RefSeq:XP_012888156.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012888156.1};
RN   [1] {ECO:0000313|RefSeq:XP_012888156.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012888156.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC       ATTTGCAT-3') and activates the promoters of the genes for some small
CC       nuclear RNAs (snRNA) and of genes such as those for histone H2B and
CC       immunoglobulins. Modulates transcription transactivation by NR3C1, AR
CC       and PGR. {ECO:0000256|ARBA:ARBA00024760}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00008879}.
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DR   RefSeq; XP_012888156.1; XM_013032702.1.
DR   AlphaFoldDB; A0A1S3GH74; -.
DR   GeneID; 105998093; -.
DR   CTD; 5452; -.
DR   OrthoDB; 4250502at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR045703; POU2F1_C.
DR   InterPro; IPR000327; POU_dom.
DR   InterPro; IPR000972; TF_octamer.
DR   PANTHER; PTHR11636; POU DOMAIN; 1.
DR   PANTHER; PTHR11636:SF46; POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 2; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   Pfam; PF19536; POU2F1_C; 1.
DR   PRINTS; PR00029; OCTAMER.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU361194};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          153..227
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000259|PROSITE:PS51179"
FT   DOMAIN          253..313
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        255..314
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          133..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          315..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..403
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  57621 MW;  8D521D510ECBA76D CRC64;
     MTQLFPSPGG AGSMVHSSMG APEIRMSKPL EAEKEGLDSP SEHTDTERNG PDTNHQNPQN
     KASPFAVSPI GPSTKDIQQL LQLQQLVLVP GHHLQPPAQF LLPQAQQSQP GLLPTPNLFQ
     LPQQTQGALL TSQPRAGLPT QPPKCLEPPS HPEEPSDLEE LEQFARTFKQ RRIKLGFTQG
     DVGLAMGKLY GNDFSQTTIS RFEALNLSFK NMCKLKPLLE KWLNDAETMS VDSSLPSPNQ
     LSSPSMGFDG LPGRRRKKRT SIETNVRFAL EKSFLANQKP TSEEILLIAE QLHMEKEVIR
     VWFCNRRQKE KRINPCSAAP MLPSPGKPTS YSPHLVTPQG GAGTLPLSQA SSSLSTTVTT
     LSSAVGTLHP SRTAGGGGGG GGAAPPLNSI PSVTPPPPAT TTNSTNPSPQ GGHSAIGLSG
     LSPSTGSTMV GLSSGLGPAL MSNNPLATIQ ALASGGTLPL TSLDGSGNLV LGAASTAPGS
     PGLVTSPLFL NHAGLPLLSA PPGVGLVSAA AAAVAASISS KSPGLSSSSS SSSSSSTCSE
     AAAQTPGGPG GPEAGSKPE
//
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