ID   A0A1S3GH91_DIPOR        Unreviewed;       376 AA.
AC   A0A1S3GH91;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Protein arginine N-methyltransferase 6 {ECO:0000256|ARBA:ARBA00040406};
DE            EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE   AltName: Full=Histone-arginine N-methyltransferase PRMT6 {ECO:0000256|ARBA:ARBA00042685};
GN   Name=Prmt6 {ECO:0000313|RefSeq:XP_012887377.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887377.1};
RN   [1] {ECO:0000313|RefSeq:XP_012887377.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887377.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_012887377.1; XM_013031923.1.
DR   AlphaFoldDB; A0A1S3GH91; -.
DR   STRING; 10020.ENSDORP00000014573; -.
DR   GeneID; 105997489; -.
DR   KEGG; dord:105997489; -.
DR   CTD; 55170; -.
DR   InParanoid; A0A1S3GH91; -.
DR   OMA; SARHICI; -.
DR   OrthoDB; 197898at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0008469; F:histone arginine N-methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR   GO; GO:0070612; F:histone H2AR3 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0070611; F:histone H3R2 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0044020; F:histone H4R3 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IEA:Ensembl.
DR   GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0036211; P:protein modification process; IEA:Ensembl.
DR   GO; GO:0010821; P:regulation of mitochondrion organization; IEA:Ensembl.
DR   GO; GO:1901796; P:regulation of signal transduction by p53 class mediator; IEA:Ensembl.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR041698; Methyltransf_25.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11006:SF73; PROTEIN ARGININE N-METHYLTRANSFERASE 6; 1.
DR   Pfam; PF13649; Methyltransf_25; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT   DOMAIN          87..183
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13649"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  41976 MW;  F1D8EF44BF7D7D84 CRC64;
     MSQTKKRRLE SEDGGGAEEG EEDRGGEGES GVVPAAPRRT KRERDQLYYE CYSDVSVHEE
     MLADRVRTEA YRLGILRNWA WLRGKAVLDV GAGTGILSVF CAQAGARRVY AVEASSIWQQ
     AREVVRLNGL EERVHVLPGP VETVELPEQV DAIVSEWMGY GLLHESMLSS VLHARTKWLK
     EGGLLLPASA ELFVAPVSDQ MLELRLGFWS QVKQYYGVDM SCLEGFATRC LMGHAEIVVH
     GLSGEDVLAR PERFAQLELA RAGLEQELEA GIGGRFRFSC YGSAPLHGFA IWFQVTFPGG
     DSEKPLVLST SPFHPATHWK QALLYLDEPV PVEQDTDISG ELTLLPSRDN PRRLRVLLRY
     KVGEQEEKTK DFAMED
//