ID A0A1S3GHW1_DIPOR Unreviewed; 655 AA.
AC A0A1S3GHW1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Serine/threonine-protein phosphatase with EF-hands {ECO:0000256|PIRNR:PIRNR000912};
DE EC=3.1.3.16 {ECO:0000256|PIRNR:PIRNR000912};
GN Name=Ppef1 {ECO:0000313|RefSeq:XP_012887597.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012887597.1};
RN [1] {ECO:0000313|RefSeq:XP_012887597.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012887597.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482,
CC ECO:0000256|PIRNR:PIRNR000912, ECO:0000256|RuleBase:RU004273};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|ARBA:ARBA00008294, ECO:0000256|PIRNR:PIRNR000912,
CC ECO:0000256|RuleBase:RU004273}.
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DR RefSeq; XP_012887597.1; XM_013032143.1.
DR AlphaFoldDB; A0A1S3GHW1; -.
DR GeneID; 105997653; -.
DR KEGG; dord:105997653; -.
DR CTD; 5475; -.
DR InParanoid; A0A1S3GHW1; -.
DR OrthoDB; 3076469at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProtKB-UniRule.
DR CDD; cd00051; EFh; 1.
DR CDD; cd07420; MPP_RdgC; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR013235; PPP_dom.
DR InterPro; IPR012008; Ser/Thr-Pase_EF-hand_contain.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF08321; PPP5; 1.
DR PIRSF; PIRSF000912; PPEF; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR000912};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|PIRNR:PIRNR000912};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR000912};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 566..601
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 606..641
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 655 AA; 76018 MW; A5C66DFBD1D65D23 CRC64;
MGCGTSSLRN KQPEKVVKAA LVIQNWYRGY RARLMARQHY ALAIFQSIEY ADEQSQMQLS
NFFSFMLEHY KHARKEDLVL VNRLRETNLQ DLKDRQSYVE LVEVPKSYDG PRLQFPLTFT
DIDVLLEAFR QQQVLHAHYV LEVLFETKKI LRKMPNFTHV TTSPSKEITI CGDLHGSLED
LLLIFYKNGL PSENNSYIFN GDFVDRGRNS IETLMVLFVS FLVYPSDLHL NRGNHEDFMM
NLRYGFTQEV LYKYKLHGKQ ILKVLEEVYT WLPIGTIIDD EILIIHGGIS ESTDLNLLHR
LERNKMKTVL MPPMSVNRDQ AVDLKKDKAG KIMASGKATS SNSLSEQLSK HEWEQIIDLL
WSDPRGKDGC YPNTSRGGGC YFGPDVTAKF LNKYHLKTII RSHECKPDGY DICHDGKVIT
VFSASDYYEE GSNRGAYIRL AHDMAPRFFQ YRATSASCLS PLYQRVEVME YSAIRILKER
IIARKTDLIR AFQLRDHSRS GKISVAQWAF SMENILELNL PWRTLSPHLV NIDSDGNVDY
MSIFQDVHIV KSLETVKSAV IETLYRYRSD LKIIFNIIDS DHSGMISIEE FRAMWKLFSS
HYNVCIDNTQ LDELAHTMDL NRDGSIDFNE FLKTFYIVHK YDKLKTPHNK FAKFK
//
