ID A0A1S3GIX4_DIPOR Unreviewed; 653 AA.
AC A0A1S3GIX4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 3 isoform X5 {ECO:0000313|RefSeq:XP_012888746.1};
GN Name=Map3k3 {ECO:0000313|RefSeq:XP_012888746.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012888746.1};
RN [1] {ECO:0000313|RefSeq:XP_012888746.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012888746.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012888746.1; XM_013033292.1.
DR AlphaFoldDB; A0A1S3GIX4; -.
DR GeneID; 105998545; -.
DR CTD; 4215; -.
DR OrthoDB; 145974at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06405; PB1_Mekk2_3; 1.
DR CDD; cd06625; STKc_MEKK3_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034879; PB1_MEKK2/3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF50; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_012888746.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transferase {ECO:0000256|ARBA:ARBA00022777,
KW ECO:0000313|RefSeq:XP_012888746.1}.
FT DOMAIN 75..154
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 389..649
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 22..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 73589 MW; 5E9E1184B0B17956 CRC64;
MDEQEALDSI MKDLVALQMS RRPRVSGYET MKNKDTGHPN RQKKHTTSSS ALLNMPTVTT
SSCAGASEKK KFLSDVRIKF EHNGERRIIA FSRPVRYEDV EHKVTTVFGQ PLDLHYMNNE
LSILLKNQDD LDKAIDILDR SSSMKSLRIL LLSQDRNHTS SSSHSGVSKQ VRIKASQSAG
DINTIYQPPE PRSRHLSVSS QNPGRSSPPP GYVPERQQHI ARQGSYTSIN SEGEFIPETN
EQCMLDPLSS AENSLSGSCQ SLDSPSFRKS RMSRAQSFPD NRQEYSDRDT QLYDKGVKGG
TYPRRYHVSV HHKDYNDGRR TFPRIRRHQG NLFTLVPSSR SLSTNGENMG LAVQYLDPRG
RLRSADSENT LSVQERSVPT KSPSAPINWR RGKLLGQGAF GRVYLCYDVD TGRELASKQV
QFDPDSPETS KEVSALECEI QLLKNLQHER IVQYYGCLRD RAEKILTIFM EYMPGGSVKD
QLKAYGALTE SVTRKYTRQI LEGVSYLHSN MIVHRDIKGA NILRDSAGNV KLGDFGASKR
LQTICMSGTG MRSVTGTPYW MSPEVISGEG YGRKADVWSL GCTVVEMLTE KPPWAEYEAM
AAIFKIATQP TNPQLPSHIS EHGRDFLRRI FVEARQRPSA EELLTHHFAQ LVY
//
