ID A0A1S3GJ09_DIPOR Unreviewed; 1468 AA.
AC A0A1S3GJ09;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=C-type mannose receptor 2 {ECO:0000313|RefSeq:XP_012888781.1};
GN Name=Mrc2 {ECO:0000313|RefSeq:XP_012888781.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012888781.1};
RN [1] {ECO:0000313|RefSeq:XP_012888781.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012888781.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012888781.1; XM_013033327.1.
DR STRING; 10020.ENSDORP00000023436; -.
DR GeneID; 105998557; -.
DR KEGG; dord:105998557; -.
DR CTD; 9902; -.
DR InParanoid; A0A1S3GJ09; -.
DR OrthoDB; 4271106at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 7.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR CDD; cd00062; FN2; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 8.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR22803:SF69; C-TYPE MANNOSE RECEPTOR 2; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF00059; Lectin_C; 8.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00034; CLECT; 8.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 8.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 3.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 8.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012888781.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1402..1425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..218
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 232..348
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 377..493
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 516..623
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 666..797
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 820..939
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 967..1089
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1120..1226
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1261..1372
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 122..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 175..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 189..216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_012888781.1"
SQ SEQUENCE 1468 AA; 165669 MW; 34152F79D82C5A42 CRC64;
PGHLLRCALL LGGLRLGRPR DSTAALPEAD IFLIFSHGLQ GCLESQGAKV RVTPACNTSL
PAQRWKWVSR NRLFNLGAMQ CLGTGWPGTN STASLGMYEC DREALSLRWQ CRTLGDQLSH
LLGGSTGNAS KPGPLERGDH TRSGQWRIYG SEEDLCARPY YEVYTIQGNS HGKPCTIPFK
YDNQWFHGCT STGREDGHLW CATTQDYGKD ERWGFCPIKS NDCETFWDKD QLTDSCYQFN
FQSTLSWREA WASCEQQGAD LLSITEIHEQ TYINGLLTGY SSTLWIGLND LDTSGGWQWS
DNSPLKYLNW ESDQPDNPNE ENCGVIRTES SGGWQNRDCS IALPYVCKKK PNSTTELTPP
DRWANVKVDC EPSWQPFQGH CYRLQAEKRS WQESKKACLR GGGDLLSIHS MAELEFITKQ
IKQEVEELWI GLNDLKLQMN FEWSDGSLVS FTHWHPFEPN NFRDSLEDCV TIWGPEGRWN
DSPCNQSLPS ICKKAGQLSQ GAAEEDHGCR KGWTWHSPSC YWLGEDQVTY SEARRLCTDH
GSQLVTITNR FEQAFVSSLI YNWEGQYFWT ALQDLNGTGS FHWLSGDEVM YTHWNRDQPG
YSRGGCVALA TGSAMGLWEV KNCTSFRARY ICRQSLGTPV TPELPGPDPT PSLAGSCPQG
WASDPKLRYC YKVFSSERLQ DKKSWIQAQG NCQELGAQLL SLASYEEEHF VANMLNKIFG
ESEPEIHEQH WFWIGLNRRD PREGQSWRWS DGLGFSYHNF DRSRHDDDDI RGCAVLDLAS
LQWVAMQCET QLDWICKIPR GTEVRKPDVS PQGRREWLRF QDAEYKFFEH HSTWAQAQRI
CTWFQAELTS VHSQDELDFL GHNLQKFSRG QEQHWWIGLH TSESDGRFRW TDGSIINFIS
WAAGKPRPPG KEKKCVYMTA SREDWGDQRC LTALPYICKR TNNTGQTQLP DLPPPALGGC
PSGWSQFLNK CFRIQGQHPQ DRVKWSEAQF FCEQQEAQLI TIANPLEQAF ITAKLPNVTF
DLWTGLHASQ RDFQWVEQEP LLYTNWAPGE PSGPSPAPSG NKPTSCAVVL HSPSAHFTGR
WDDRSCTEEA HGFICQKGTD LSLSPSPAAS PPAPGTELSY LNGTFRLLQK PLRWHDALLL
CESRNTSLAH VPDPYTQAFL TQAARGLRVP LWIGLASEEG SRQYSWVSEE PLSYMNWQDG
EPQHSGGCTY LDVDGAWHTT SCDTKLQGAV CGVNRGPPPP RRINYHGSCP QGLADSAWIP
FREHCYSFHM ELLLGHKEAL QRCQRVGGAV LSILDEMENV FVWEHLQSSE GQNRGAWLGM
NFNPKGGTLV WQDNTVVNYS NWGSPGLGPS MLSHNSCYWI QSNSGLWRPG ACTNITMGVV
CKLPRVEESS FSPSAALPEN PAALVVVLMA VLLLLALITA ALILYRRRQS VERGTFEGAR
YSRSSSGPGE ATEKNILVSD MEMNEQQE
//
