ID A0A1S3GJ66_DIPOR Unreviewed; 708 AA.
AC A0A1S3GJ66;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=G2/M phase-specific E3 ubiquitin-protein ligase isoform X1 {ECO:0000313|RefSeq:XP_012888923.1, ECO:0000313|RefSeq:XP_012888924.1};
GN Name=G2e3 {ECO:0000313|RefSeq:XP_012888923.1,
GN ECO:0000313|RefSeq:XP_012888924.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012888923.1};
RN [1] {ECO:0000313|RefSeq:XP_012888923.1, ECO:0000313|RefSeq:XP_012888924.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012888923.1,
RC ECO:0000313|RefSeq:XP_012888924.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012888923.1; XM_013033469.1.
DR RefSeq; XP_012888924.1; XM_013033470.1.
DR GeneID; 105998670; -.
DR KEGG; dord:105998670; -.
DR CTD; 55632; -.
DR OrthoDB; 2899995at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd15669; ePHD_PHF7_G2E3_like; 1.
DR CDD; cd15496; PHD_PHF7_G2E3_like; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042013; PHF7/G2E3_ePHD.
DR InterPro; IPR042012; PHF7/G2E3_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12420:SF37; G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR12420; PHD FINGER PROTEIN; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 11..128
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 534..705
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 668
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 708 AA; 81012 MW; F9AD910A314021D5 CRC64;
MNENKPGDSQ NLACVFCRKT DDCPYKYGEK KTNEKWNLTV HYHCLLMSSG IWQRGKEEEG
LYGFLIEDIK KEVHRASKLK CSVCKKSGAS IGCVAPRCKR SYHLPCGLER ECIFQFTGNF
ASFCWSHRPI QITTSNNYRD SLPCTICLEY IEPIPTYSVL QSPCCKNAWF HRDCLQVQAI
NAGIFFFRCT ICNNSEIFQK EMLKMGIHIP EKDASWELEE NAYQDLLQHH ERCDVRRCRC
KEGREYNEPD SKWEIKRCQC CGSSGTHLAC SSLRSWEQNW ECLECRSIIY NSGFKSVGFQ
KAKKHAAPKS NKVAITDCLL EESSPKLQKL SSGPQHEELL RQGSKFRRDI STILIELGFQ
IKKKTEKLYI NKANIWNSAI DEFKNFNPSY TIEVSYVNEN DGFGKECLGS KQEFLSLLMH
HLANSSLFEG SLSKNLSLNS QALEENLYYE AGKILAISLV HGGPSPGFFS KTLFNCLVYG
PENTEPVLED VSDFDVAQII IRINTAADIT DLNSVINECY NYLDVIGCLR HVTTLNDKYM
LAKDVLVYQV IKRVQIPFES FKQGLKTLGV LEKIQTYPEA FYDILCHKPE TLSAKVLSDL
FEMHTLPDVQ TSGYWKNYLQ NIEEGKSATT MEDILIFATG CNSVPPSGFK PTPSIEYLHT
DFPVGNKCNN CLVLPITKTY KEFEESMDFT IRNTIKLEKE EYSHYVEH
//
