GenomeNet

Database: UniProt
Entry: A0A1S3GLS9_DIPOR
LinkDB: A0A1S3GLS9_DIPOR
Original site: A0A1S3GLS9_DIPOR 
ID   A0A1S3GLS9_DIPOR        Unreviewed;      1140 AA.
AC   A0A1S3GLS9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=Insr {ECO:0000313|RefSeq:XP_012888957.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012888957.1};
RN   [1] {ECO:0000313|RefSeq:XP_012888957.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012888957.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171,
CC         ECO:0000256|RuleBase:RU000312};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012888957.1; XM_013033503.1.
DR   AlphaFoldDB; A0A1S3GLS9; -.
DR   STRING; 10020.ENSDORP00000024273; -.
DR   GeneID; 105998714; -.
DR   KEGG; dord:105998714; -.
DR   CTD; 3643; -.
DR   InParanoid; A0A1S3GLS9; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd00064; FU; 1.
DR   CDD; cd05061; PTKc_InsR; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040969; Insulin_TMD.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   PANTHER; PTHR24416:SF535; INSULIN RECEPTOR; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF17870; Insulin_TMD; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00261; FU; 2.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000256|ARBA:ARBA00023137};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW   ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000312};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   TRANSMEM        714..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          609..703
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          779..1054
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1118..1140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         813
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1140 AA;  129202 MW;  5A848B92A6D039D4 CRC64;
     MDIRNNLTRL HELENCSVIE GHLQILLMFK TRPEDFRYLS FPKLIMITDY LLLFRVYGLE
     SLKDLFPNLT VIRGSRLFFN YALVIFEMVH LKELGLYNLM NITRGSVRIE KNNELCYLAT
     IDWSRILDSV EDNYIVLNKD DKEECGDICP GTGKGKANCP ATVINGHFVE RCWTHSHCQK
     VCPTICKSHG CTADGLCCHS ECLGNCSAPD DPTKCVACRN FYLEGRCVPT CPPPYYHFQD
     WRCVNFSFCL DLHNKCKNSR RQGCHQYVIH DNKCIPECPS GYTMNSTNLM CTPCLGPCPK
     ICHLLEGEKT IDSVTSAQEL RGCTVVNGSL IINIRGGNNL AAELEANLGL IEEISGYLKI
     RRSYALVSLS FFRKLRLIRG ETLEVGNYSF YALDNQNLRQ LWDWSKHNLT IINGKLFFHY
     NPKLCLSEIH KMEEVSGTKG RQERNDIALK TNGDQASCEN ELLKFSFIRT SYDKIMLKWE
     PYWPPDFRDL LGFMLFYKEA KASSGNGVED SRPSRKRRSL GDVVNVTMMP PVIPIFPNVS
     STVVPTTQEP PRPVEKVVNK ESLVISGLRH FTGYRIELQA CNQDAPEERC SVAAYVSART
     MPEAKADDIV GPVTHEIFEN NVVHLTWQEP KEPNGLIVLY EVSYRRYGDE ELHLCVSRKH
     FALEQGCRLR GLPPGNYSVR IRATSLAGNG SWTEPTYFYV TDYLDVPSNL AKIIIGPLIF
     VFLFSGVIGS IYLFLRKRQP DGPMGPLYAS SNPEYLSASD VFPCSVYVPD EWEVPRDKIT
     LLRELGQGSF GMVYEGNAKD IIKGEAETRV AVKTVNEAAS LRERIEFLNE ASVMKGFTCH
     HVVRLLGVVS KGQPTLVVME LMAQGDLKSY LRSLRPDAEN NPGRPPPTLQ EMIQMAGEIA
     DGMAYLNAKK FVHRDLAARN CMVAHDFTVK IGDFGMTRDI YEMDYYRKGG KGLLPVRWMA
     PESLKDGVFT ASSDMWSFGV VLWEITSLAE QPYQGLSNEQ VLKFVMDGGY LDQPDNCPER
     VTNLMHMCWQ FNPKMRPTFL EIVNLLKDDL HPSFPEVSFF HSEENKGPEN EELEMEFEGD
     MENVPLDRSS HCQREEAGGR EGGVSSLGLK RSYEEHIPYT HMNGGKKNGR ILTLPRSNPS
//
DBGET integrated database retrieval system