ID A0A1S3GMK1_DIPOR Unreviewed; 1788 AA.
AC A0A1S3GMK1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Brefeldin A-inhibited guanine nucleotide-exchange protein 1 {ECO:0000313|RefSeq:XP_012889930.1};
GN Name=Arfgef1 {ECO:0000313|RefSeq:XP_012889930.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012889930.1};
RN [1] {ECO:0000313|RefSeq:XP_012889930.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012889930.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012889930.1; XM_013034476.1.
DR STRING; 10020.ENSDORP00000010985; -.
DR GeneID; 105999451; -.
DR KEGG; dord:105999451; -.
DR CTD; 10565; -.
DR InParanoid; A0A1S3GMK1; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF137; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 673..862
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 23..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1788 AA; 202310 MW; 3C484D6CFE424CD0 CRC64;
MRIEVPDKLG QKHEICHKSR LRRNEIKAET EKQSPPHGEA KVGSSTLPPV KSKTNFIEAD
KYFLPFELAC QSKCPRIVST SLDCLQKLIA YGHLTGNAPD STTPGKKLID RIIETICGCF
QGPQTDEGVQ LQIIKALLTA VTSQHIEIHE GTVLQAVRTC YNIYLASKNL INQTTAKATL
TQMLNVIFAR MENQALQEAK QMEKERHRQH HHLLQSPVSH HQPESPQLRY LPPQTIDHIS
QEHEGDLDPH TNDVDKSLQD DTEPENGSDI SSAENEQTEA DQATAAETLS KNDVLYDGEN
HDCEEKPQDI VQSIVEEMVN IIVGEMGEGT TINANTDGNI GAIEDGSDSE NIQANGIPGT
PISVAYTPSL PDDRLSVSSN DTQESGNSSG PSPGAKFSHI LQKDAFLVFR SLCKLSMKPL
SDGPPDPKSH ELRSKILSLQ LLLSILQNAG PVFRTNEMFI NAIKQYLCVA LSKNGVSSVP
EVFELSLSIF LTLLSNFKTH LKMQIEVFFK EIFLYILETS TSSFDHKWMV IQTLTRICAD
AQSVVDIYVN YDCDLNAANI FERLVNDLSK IAQGRGSQEL GMSSVQELSL RKKGLECLVS
ILKCMVEWSK DQYVNPNSQT TLGQEKPSEQ EMSEMKHPET INRYGSLNSL ESTSSSGIGS
YSTQMSGTDN PEQFEVLKQQ KEIIEQGIDL FNKKPKRGIQ YLQEQGMLGT TPEDIAQFLH
QEERLDSTQV GEFLGDNDKF NKEVMYAYVD QHDFSGKDFV SALRMFLEGF RLPGEAQKID
RLMEKFAARY LECNQGQTLF ASADTAYVLA YSIIMLTTDL HSPQVKNKMT KEQYIKMNRG
INDSKDLPEE YLSAIYNEIA GKKISMKETK ELTIPTKSTK QNVASEKQRR LLYNLEMEQM
AKTAKALMEA VSHVQAPFTS ATHLEHVRPM FKLERDAYVQ ALARFTLLTV SSGITEMKQK
NIDTIKTLIT VAHTDGNYLG NSWHEILKCI SQLELAQLIG TGVKPRYISG TVRGREGSLT
GTKDQAPDEF VGLGLVGGNV DWKQIASIQE SIGETSSQSV VVAVDRIFTG STRLDGNAIV
DFVRWLCAVS MDELLSTTHP RMFSLQKIVE ISYYNMGRIR LQWSRIWEVI GDHFNKVGCN
PNEDVAIFAV DSLRQLSMKF LEKGELANFR FQKDFLRPFE HIMKRNRSPT IRDMVVRCIA
QMVNSQAANI RSGWKNIFSV FHLAASDQDE SIVELAFQTT GHIVTLVFEK HFPATIDSFQ
DAVKCLSEFA CNAAFPDTSM EAIRLIRHCA KYVSERPQAF KEYTSDDMNV APEDRVWVRG
WFPILFELSC IINRCKLDVR TRGLTVMFEI MKTYGHTYEK HWWQDLFRIV FRIFDNMKLP
EQQTEKAEWM TTTCNHALYA ICDVFTQYLE VLSDVLLDDI FAQLYWCVQQ DNEQLARSGT
NCLENVVILN GEKFTLEIWD KTCNCTLDIF KTTIPHALLT WRPTSGETSL PPQSPVSEKQ
LDTVSQKSVD IHDSIQPRST DNRQQAPSVS ASTVNEEVNK IKSSAKFPEQ KLFAALLIKC
VVQLELIQTI DNIVFFPATS KKEDAENLAA AQRDAVDFDV RVDTQDQGMY RFLTSQQLFK
LLDCLLESHR FAKAFNSNNE QRTALWKAGF KGKSKPNLLK QETSSLACGL RILFRMYMDE
SRVSAWEEVQ QRLLNVCSEA LSYFLTLTSE SHREAWTNLL LLFLTKVLKI SDNRFKAHAS
FYYPLLCEIM QFDLIPELRA VLRRFFLRIG VVFQISQPPE QELGINKP
//