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Database: UniProt
Entry: A0A1S3GQC6_DIPOR
LinkDB: A0A1S3GQC6_DIPOR
Original site: A0A1S3GQC6_DIPOR 
ID   A0A1S3GQC6_DIPOR        Unreviewed;      2677 AA.
AC   A0A1S3GQC6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X1 {ECO:0000313|RefSeq:XP_012890469.1};
GN   Name=Itpr3 {ECO:0000313|RefSeq:XP_012890469.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha;
OC   Heteromyidae; Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012890469.1};
RN   [1] {ECO:0000313|RefSeq:XP_012890469.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012890469.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   RefSeq; XP_012890469.1; XM_013035015.1.
DR   GeneID; 105999871; -.
DR   CTD; 3710; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000081671; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000081671};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_012890469.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2207   2232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2244   2262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2274   2294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2330   2355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2375   2397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2504   2527       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    369       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      375    431       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2635   2662       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2677 AA;  304701 MW;  0D5D07E7E219FAF8 CRC64;
     MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGIGRTGR RNAGEKIKYR LVAVPHGSDI
     ASLFELDPTT LQKTDSFVPR NSYVRLRHLC TNTWIQSTNV PIDIEEERPI RLMLGTCPTK
     EDKEAFAIVS VPVSEIRDLD FANDASSMLA SAVEKLNEGF ISQNDRRFVI QLLEDLVFFV
     SDVPNNGQNV LDIMVTKPNR ERQKLMREQN ILKQIFGILK APFRDKGGEG PLVRLEELSD
     QKNAPYQHMF RLCYRVLRHS QEDYRKNQEH IAKQFGMMQS QIGYDILAED TITALLHNNR
     KLLEKHITKT EVETFVSLVR KNREPRFLDY LSDLCVSNHV AIPVTQELIC KCVLDPKNSD
     ILIQTELRPL KEMAQSHEYL SIEYSEEEVW LTWTDKNNEH HEKSVRQLAQ EARAGNAHDE
     NVLSYYRYQL KLFARMCLDR QYLAIDEISQ QLGVDLIFLC MADEMLPFDL RASFCHLMLH
     VHVDRDPQEL VTPVKFARLW TEIPTAITIK DYDSNLNTSR DDKKNKFAST MEFVEDYLSN
     VVGEAVPFAN EEKNKLTYEV VSLAHNLIYF GFYSFSELLR LTRTLLGIID CVQGPPAMLQ
     VFEDPGGKNV RRSIQGVGHM MSTMVLSRKQ SVFGAPSLPA GAGAAEPLDR SKFEDNEDIV
     VMETKLKILE ILQFILNVRL DYRISYLLSV FKKEFVEVFP MQDSGADGTA PAFDSTTANM
     NLDRIGEQAE AMFGVGKTSS MLEVDDEGGR MFLRVLIHLT MHDYAPLVSG ALQLLFKHFS
     QRQEAMHTFK QVQLLISAQD VENYKVIKSE LDRLRTMVEK SELWVDKKGS GKGEEGEAGT
     AKDKKERPTD EEGFLQPSGE KSSENYQIVK GILERLNKMC GVGEQMRKKQ QRLLKNMDAH
     KVMLDLLQIP YDKGDAKMME ILRYTHQFLQ KFCAGNPGNQ ALLHKHLHLF LTPGLLEAES
     MQHIFLNNYQ LCSEISEPVL QHFVHLLATH GRHVQYLDFL HTVIKAEGKY VKKCQDMIMT
     ELTNAGEDVV VFYNDKASLA HLLDMMKAAR DGVEEHSPLM YHISLVDLLA ACAEGKNVYT
     EIKCTSLLPL EDVVTVVTHE DCITEVKMAY VNFVNHCYVD TEVEMKEIYT SNHIWTLFEN
     FTLDMARVCN KREKRLADPT LEKYVLTVVL DTISAFFSSP FSENSTSLQT HQTIVVQLLQ
     STTRLLECPW LQQQHKSSVE ACVRTLAMVA KGRSISLPMD LDAHISVLLS SGSSSAAAAQ
     RNAASYKTAT RTFPRLTPTA NQWDYKNIIE KLQDIITALE ERLKPLVQAE LSVLVDVLHW
     PELLFLEGSE AYQRCESGGF LCKLIQHTKD LMESEEKLCI KVLRTLQQML LKKTKYGDRG
     NQLRKMLLQN YLQNRKSSSR GDLPDPMGTG LDQDWSAIAA TQCRLDKEGA TKLVCDLITS
     TKNEKIFQES IGLAIRLLDG GNTEIQKSFY NLMMSDKKSE RFFKVLHDRM KRAQQETKST
     VAVNMNDLGS QPHEDREPAD PTTKGRLASF SIPGSSSRYS LGPSLHRGHE VGERVQSNEM
     GTSVLIMQPI LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG
     LLGLYINEDN VGLVIQTLET LTEYCQGPCH ENQTCIVTHE SNGIDIITAL ILNDISPLCK
     YRMDLVLQLK DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEERENSE
     VSPREVGHNI YILALQLSRH NKQLQHLLKP VKRIQEEEAE GISSMVGARE GRIWLSLNNK
     QLSQMLKSSV PAQEEEEDPL AYYENHTSQI EIVRQDRSME QIVFPVPGIC QFLTEETKHR
     LFTTTEQDEQ GSKVSDFFDQ SSFLHNEMEW QRKLRSMPLI YWFSRRMTLW GSISFNLAVF
     INIIIAFFYP YVEGASTGVL GSPLISLLFW ILICFSIAAL FTKRYSIRPL IVALILRSIY
     YLGIGPTLNI LGALNLTNKI VFVVSFVGNR GTFIRGYKAM VMDMEFLYHV GYILTSVLGL
     FAHELFYSIL LFDLIYREET LFNVIKSVTR NGRSILLTAL LALILVYLFS IVGFLFLKDD
     FILEVDRLPG NHSRASPLGV PHGAATFVGT CSGDKMECAS GVAVPEVLEE DEELDSTERA
     CDTLLMCIVT VMNHGLRNGG GVGDILRKPS KDESLFPARV VYDLLFFFIV IIIVLNLIFG
     VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVS FEEHIKLEHN MWNYLYFIVL
     VRVKNKTDYT GPESYVAQMI KNKNLDWFPR MRAMSLVSNE GEGEQNEIRI LQDKLSSTMK
     LVSHLTAQLN ELKEQMTEQR KRRQRLGFVD VQNCMSR
//
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