ID A0A1S3GX36_DIPOR Unreviewed; 1203 AA.
AC A0A1S3GX36;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Caskin-2 {ECO:0000313|RefSeq:XP_012893351.1};
GN Name=Caskin2 {ECO:0000313|RefSeq:XP_012893351.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012893351.1};
RN [1] {ECO:0000313|RefSeq:XP_012893351.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012893351.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_012893351.1; XM_013037897.1.
DR AlphaFoldDB; A0A1S3GX36; -.
DR STRING; 10020.ENSDORP00000021548; -.
DR GeneID; 106003112; -.
DR KEGG; dord:106003112; -.
DR CTD; 57513; -.
DR InParanoid; A0A1S3GX36; -.
DR OrthoDB; 25046at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 281..347
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 488..551
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 557..621
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 353..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..777
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..996
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1136
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 126846 MW; E3AEABF37A753E0E CRC64;
MGREQDLILA VKNGDVTCVQ KLVAKVKAAK TKLLGSTKRL NVNYQDADGF SALHHAALGG
SLELIALLLE AQATVDIKDS NGMRPLHYAA WQGRLEPVRL LLRASAAVNA ASLDGQIPLH
LAAQYGHYEV SEMLLQHQSN PCLVNKAKKT PLDLACEFGR LKVAQLLLNS HLCVALLEGE
AKDPCDPNYT TPLHLAAKNG HREVIRQLLR AGIEINRQTK TGTALHEAAL YGKTEVVRLL
LEGGVDVNIR NTYNQTALDI VNQFTTSQAS REIKQLLREA SGILKVRALK DFWNLHDPTA
LNVRAGDVIT VLEQHADGRW KGHIHESQRG TDRVGYFPPG IVEVVSKRVG IPVPRVPSAP
TTLRPGFSRT PQPPADDALH PLAYGQLPRV GLSPDSPAGD RNSVGSEGSV GSIRSAGSGQ
SSEGTNGHST GLLIENAQPL PSAGEDQVLP GLHAPPLADT LSHHPLISHR SGEIFTQDVR
PEQLLEGKDA QAIHNWLSEF QLEGYTAHFL QAGYDVPTIS RMTPEDLTAI GVTKPGHRKK
IAAEIAQLSI SEWLPNYIPT DLLEWLSALG LPQYHKQLVS SGYDSMGLVA DLTWEELQEI
GVNKLGHQKK LMLGVRRLAE LRRGLLQGEA LGEGGRRLAR GSELMTIDGL ENGEGPAMAG
PRLLTFQGSE LSPELQAAMA GGGPEPLPLP PARSPSQESI GARSRGSGHS QEQSAPQPSA
GGDPGTLQER NLPEGTERPS KLCFPPPGQG PAPYVFMYPQ VSPSSPAPGP PPGAPRAFSY
LAGPLATPPD PPRPKRRSHS LSRPGPAEGE AEGEAEEPVG SALGSYATLT RRPGRSTLAR
TSPSPAPARG TPRSQSFALR ARRKGPPPPP PKRLSSVSGS TEPPPLDGSP GPKDGATGPR
RRTLSEPSGP SEPPSLPSPA GPVSDTEEEP SPEGTPPSRG SSGEGLPFAE EGNLTIKQRP
KPAGPPPRET PVPPGLHFNL TESDTVKRRP KCREREPLQT ALLAFGVAGA TPSPSAPPPS
QAPSESSLSE SSSPPQPEPS SLATQGAPVP PLSPGTQTPT APVASSAGPS LESSANHRPP
AEPEHTAAPT ALLKVPGAGT APKAVSVACT QLAFSGPKLA PRPGPRPVPP PRPESTGGAV
GPGRAQQRLE QTSSSLAAAL RAAEKSIGAE EREGPPGTST KHILDDISTM FDALADQLDA
MLD
//
