ID A0A1S3H024_LINUN Unreviewed; 1328 AA.
AC A0A1S3H024;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Enhancer of mRNA-decapping protein 4 isoform X2 {ECO:0000313|RefSeq:XP_013379353.1};
GN Name=LOC106150882 {ECO:0000313|RefSeq:XP_013379353.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013379353.1};
RN [1] {ECO:0000313|RefSeq:XP_013379353.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013379353.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
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DR RefSeq; XP_013379353.1; XM_013523899.1.
DR EnsemblMetazoa; XM_013523899.1; XP_013379353.1; LOC106150882.
DR GeneID; 106150882; -.
DR OrthoDB; 2911539at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 104..438
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 289..322
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1199..1319
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 472..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 883..910
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 484..499
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..784
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..821
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1328 AA; 146286 MW; 2E8653939693C317 CRC64;
METSSGSSSF NTTEASQLLK DILQGNTGVS SISSSVTDGD FARSARDISG ESGASFADAV
KAHLPKQQII LQGNDSANSF SVYGRDVSII ASQASGAAER VPASNKVKIT PMVNFEWEPK
YYIGNLVAIH RDGIHMSYVL TGKSGGCVRV INRKTAERAL LKGFTGRVMD VAFAHHTLVI
IAAVDEMGNL FVHQADDTDD GKILTACLLH VVRPAETPPS SYHRVIWCPY IPDEEEEQGT
EDMPTHDAGK LLVVTHDEKA ELWSVDMVNG EYGTGPHRAE DIDIGFLAIE NHTRPIVDAA
FSPDGTALAT ASLDGQVKFF QVYMQDKATP RCLHEWKPHD GLPLSSLFFL DDHKNPKPEV
QFWKFALTGA NDNRELKIWS CESWTCLQTL RFVSPPDLPS NFQVEPSLKA CLDLSANYMV
LADTKRKVLN VLQLYQDAEH GTAHVSSVSE FLLTQPCLSM AILEAGSKVV KKSSTQEQSG
EMNSGNLDED EDDEDQEARD EDGIKGCLVR LYTVQHRALQ ELQIHFELQT SVPNLPAPSI
SSISQDGTAL RDALTDISMD TVTSLSDVEY KAKDAAGNNS QPLLLTPDAF TSSPRKSSES
LHSSNTSSSF THVSALNEEH GASVMSPSSS VTLTPNSSHV PTPTTLPLPP VTPGEENRLT
TTPKHTPQHT PKLNLSAAEQ DLDDFLGSPT STSSSIKGNQ PPSFQNGGIK VGDRGGGQGD
MLDELFGSQG TKRQHLQSSS SSTTSIEVGQ IMDAKPSYVV GETAQEEEEE EEEEEGEEEE
EEEEQHSYGM RVWPQAPKVT DEGQEKGDGT EDQDEDVKIE EETEEHTGRT DSSSEREEIS
SSSESPKKKS HRHPSTRQRT SSYSPTSARS LEAGSIPQLQ DTMQNIMSLL QDQRQELASL
KAQLHQQREH NALMEGVLGN RLETALEQYG HSQDLRLREA LSSTHSARQH DSHQVVNTLS
EALVNKVIAS LDTAVKTEIK NSVVPTIQRM IHPLQEHLHR EMAQKLTATD SVMKDNIGKM
VRSKQTVEAI GQAAGQAVSG TVISAYRETF QNTILPGFER SCQHMTGQLN EAFHKGTQEY
VQQLQSQMDS VNQRQNETKD YVRSQLQAAM EQFKSSTQSV QQRLVTSVQT EVNKHLQQTM
SGLEEAMITR LKSTIRDEVS DALRDQQERL NESIAQAMRS TAATPVPGFV DPQQQQAAIH
HLLKQGQLNN AFQQALSASD LSLVMYVCET VNPSQVFNQT PCPLQQPVLL SLIQQLSADL
GNNTELKHKY LEEAVMNLEP TNSLTREHMP AVLNNLVQKL LEYINANPTD RMTRQLRMLL
MASQSLLK
//
