ID A0A1S3H5S6_LINUN Unreviewed; 1252 AA.
AC A0A1S3H5S6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106151935 {ECO:0000313|RefSeq:XP_013380826.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013380826.1};
RN [1] {ECO:0000313|RefSeq:XP_013380826.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_013380826.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR RefSeq; XP_013380826.1; XM_013525372.1.
DR AlphaFoldDB; A0A1S3H5S6; -.
DR STRING; 7574.A0A1S3H5S6; -.
DR EnsemblMetazoa; XM_013525372.1; XP_013380826.1; LOC106151935.
DR GeneID; 106151935; -.
DR KEGG; lak:106151935; -.
DR InParanoid; A0A1S3H5S6; -.
DR OrthoDB; 2903434at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd14550; R5-PTP-2; 1.
DR CDD; cd14549; R5-PTPc-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013380826.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1252
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010324409"
FT TRANSMEM 559..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 132..232
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 237..331
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 332..435
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 439..548
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 644..911
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 828..902
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 944..1202
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1121..1193
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1252 AA; 142143 MW; B71906E69C0D2614 CRC64;
MESAIYLPLL LCFFVFLCKA ENKVIKSRRG SVVTLPCDHG GINRANIDQV LWFKGTQSLL
SWSNIGVTST AGTDPKAQER ITIIEADFSL RLNSVVMEDS GQYKCYVEYT SGNDTLMANS
TLLLTIQDVP SPPGKPIISN IQSRSFHVTF TASALSNNSP IKYYNVHVIQ RGGNWENAIS
FQVHATSNLS NILISSAGII RPYRNYVVRV SAINEIGNSS ASEETEVQTA EDEPLAKPTI
LEIRNLTNSS VQLHWQDPSP DTLNGELLGY KIVYKRHPEG NLHPITVPNP DEKFCNITHL
KPHTRYLVAL QLYNKAGESP KAEEIFLTDE GVPNRPRITD ISNQTSTSFV VAWVIPTEPN
GIITSYKVRW NETDSSGNRI GQTKAETIRV EEGFKPTMKI RWLKPYTDYT VRVVAHTSKG
EGEESVQQSV ITDVSNPGRP QRVLVKQNET GSVLLTWHSP ISFTRHIDRY LIKYYKEEDG
ALGAVEKTLD VNPERREDAR NEPEEFALHG LEEGVVYKFS VAAATKSLFS SEYKIGQYTV
PVTLTLEGKR ITTDAPEPAM GLAAILGVIA AVAVILIVPI VLAIVFLLRR KKNYQETATK
GSDDNISQPL LLMELYGRSN YESVSIENWA DHVRKMHADG DLRFSEEYDD INNSVNKNIT
QDAAYMDENK PKNRYVNILP FDHTRVVLKP MSKHNDYINA NFVDGYHKAK AYIATQGPLP
NTFEDFWRMV WDQNSVIVVM ITNLEEKGRR KCDKYWPNEV GHTETYGNMQ VEYLDEDERA
CYTIRKFCLR NQKAKRVSTR VKHSAFERII YQYHYTDWPD HGVPDYTLPV LTLVQKSSRH
NPEGAGPIIV HCSAGVGRTG TYIVLDSMIR QILDKRTVNV CGFLTHIRHQ RSFLVQTEDQ
YIFIHDALLE YIQKDGDTEV LNCKLKEFVE ENLTFCNAEG ECLLDRQYQL VTEYKPKDHE
FSPAHMIYNK NKNRSERLLP VDKSRVHLPK QPGIDGSDYI NATFLQGYFK INEFVITQHP
LGTTQEDFWR MVWDQNSATI VMLSEVTKDG EFPEFWQGKD ETQEIDSGNF KVTQTGEDFS
QIHNITRDFL IESKQDDYEL TSRIISTTAW PESCTPLHTV LEFIDTVDSW HKEHQNGPII
VIDKEGGSVA GTFCALYSLN NQRKHEDGVD VYSLAKTYHL MRPGIFSSKD DYHFLYKVMG
SIVESQPDIL MDIKGRIGSS ESLNHGNNGQ PLSTWAHGLS LKRNEEQTTT TV
//
