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Database: UniProt
Entry: A0A1S3H6H5_LINUN
LinkDB: A0A1S3H6H5_LINUN
Original site: A0A1S3H6H5_LINUN 
ID   A0A1S3H6H5_LINUN        Unreviewed;      2782 AA.
AC   A0A1S3H6H5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X9 {ECO:0000313|RefSeq:XP_013381720.1};
GN   Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381720.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381720.1};
RN   [1] {ECO:0000313|RefSeq:XP_013381720.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26383154;
RA   Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M.,
RA   Khalturina M., Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT   "The Lingula genome provides insights into brachiopod evolution and
RT   the origin of phosphate biomineralization.";
RL   Nat. Commun. 6:8301-8301(2015).
RN   [2] {ECO:0000313|RefSeq:XP_013381720.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2018) to UniProtKB.
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DR   RefSeq; XP_013381720.1; XM_013526266.1.
DR   GeneID; 106152615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013381720.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2222   2245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2280   2302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2351   2378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2405   2426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2438   2459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2471   2501       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    350       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      365    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2613   2633       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2782 AA;  320607 MW;  FA72FE9F2AF131BA CRC64;
     MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
     QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
     IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
     DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
     SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
     ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
     DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
     SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
     QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
     YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
     LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
     HDKVSFDAKT CHIHLTGADV YLIERGQYIH KEHNVVYIST DAGHTWVPLH QFANADSPYY
     SEEEYLYLDR QLDLLGKLCK GRNQFSIRVI TKDLDILTWE NTFVCLRSEL LPPSLRAKYC
     SLIIDLFVDV GASHSVLDQH TLVFVYEDID NPRPLYSTKS QVATNVLFLA QELGTVFPVM
     RDWIQEFVES NPEMYSSQVG QNKLIEQVMR LLCYLVRFGC YCSADEIRIL LKPLMIMLDG
     RNDRPFPKNA EIQNSKEVKK LVKQYRETDR FEKSAETKAL VDAKYQGLSV LELLFTFQSN
     TRLESFVSKF KTAETTANAK KKKHRSVLSP LVDDSYDAFN TSKKNLRKQK KFLHELRAMF
     ESSSYFDVEY ITNISLDLSN YKYEKMLTQS LNILNKYYSS KTDMFKIAIP TLVLTTQESC
     KIHIDIMRQL PLVRHLAKCS YNMEQAEAMS VVFDQFVLFT HLRDEPTLRH PMNQKILINH
     GVLDLIFAIL SQEVDVQITE QAAPMELVFG KALNLLRFLA QGNEDVQAKM NDRLDSLMNI
     KLVPSHLAIA LREVFAGNQN NCLKIQPKQI LKIVHLAGEN QDRAPEFLDL LGSIVKVELL
     ELPLKRNQGL VMKYLMQNYH KAAYLFDQSQ EDRLRILTSK TGNSHQRYLI SLVDLLAKCA
     EGENRYIESL CQTIMPIEEI MDVLNNHFID NNLKSPYLRY LMWVYMKTAG TMIESGAGDL
     PHDRHVWIYI QALAREAESL KTYISENEVK TVEVMRAPPP KGAVAEMDDS DGAAHATLFY
     FFDAVLPFLQ TFFTKFYSPD KELYPDELEY VDQLAHSLVL WCDRVGAVLC NATHLKVLIG
     CVPSVLQSSS IPKNVMEGFI EQYGNGRCLR DPTRETIDTY TIYYQNEDEL NKKFRAFSVN
     CSLVYGGHNT VTAQLKHKSK REYTEIGGDE DLPLGEEFQA HVRCFVKHNE KNIAKRYQNV
     SKLVQQLAVS ANAVNPKDGT YENDELDIKS LQILRAVIHN EERKLREDWE ENTQDKKVQK
     QLKVILEVQN TLNSYSAVEE VLPHLGRPSN AIVRESLAFL SIMLFNANRN VQRTMLDVFK
     SMRTETFFFA IRIRLEIAAN GLKERRALAT QHEARVKESM TQAKSLQTNL TVGRKAMKDI
     QAIERSRRQS RLMKGARANS LRALQRDRQS GLTSISPASS KCNSLQRFKL PNGSLNEETP
     LVFGSNHNDI ELNEVMVEGS DNLSVDVEED DVLDGLEFKD EGYIVLVLRL LAAMCDGQNQ
     SIQDYLRDQP DNIKSINVVA DTAQFVNVVY SNITASTIDL VIQLFSTLNE FTAGNQANRV
     VLLDNKVVDY INFILRAGKY EGISMEMQLE LREVIANLLV SLIEENGPEP IKVAREVKDT
     VDKEAVYRCM VDCYSIHQPP TYKAKISTNM GDNMKNLSQM GGGLLREIME KNKKNDLKDK
     AYEVGFLYFL LMARFYDIDP VLNEKAGLVI TPDQMAAYNY YKKNSMSIEL MKDGNLQKVH
     FRVKNKNVLR EEVKEKLKWD VDRSSPSNKI RDLMAWSKDI LKDIYYQRKM LRNPIAVFFT
     KFWLLWNYLV ILLSVAINVL MLWAWKAPYD MSQAPENMTH LDHAIYNPNP DTSSVEIYDL
     LLYAMGGTHN LFSLFVLISY FLSNHPKCPS LSAIPNLCRR LCGRKDEEED EIAHEVDCEK
     AKRQSKLDVK FFSLATFYYV IFVGMSVAGT FFHGYFFAFH LLNIVNNNQI LQGVIKAVTQ
     NGVSLLWVGI LGVIIFYIYA LISFAFMRAL FLPKDEEYCG TLLECSVTVI RYGLIGAIFD
     RLTLPESENN FIAFAVVAVF HLSFFILITT IGLNVILGIV VDTFSELRDL KWTAESDMRD
     TCFICSRGSH DFEHHGNGFL KHAREEHNMW AYIFFFIHLD DTKSNDYTAL DLHVAQALQR
     EQYEFFPMNC ALSLTGEEDG TDEKIDAVLE KVTELLRRQR EEESKRMREE EHRRQKQWQE
     MYRKALSGSH DTLAAAIEGP RRPEDREGDA ARYSDDDDSR GGVRTPETIT LRDSATSTEE
     SPPRESPRRT EEPPETPREL LPPPPPPPSD GPHDVPPERP HDEPHALDMA PHVSEVAFPL
     TAPEDFPSPT FSDDDDFDDT RL
//
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