ID A0A1S3H6H9_LINUN Unreviewed; 809 AA.
AC A0A1S3H6H9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|RefSeq:XP_013381725.1};
GN Name=LOC106152617 {ECO:0000313|RefSeq:XP_013381725.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381725.1};
RN [1] {ECO:0000313|RefSeq:XP_013381725.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_013381725.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013381725.1; XM_013526271.1.
DR AlphaFoldDB; A0A1S3H6H9; -.
DR STRING; 7574.A0A1S3H6H9; -.
DR EnsemblMetazoa; XM_013526271.1; XP_013381725.1; LOC106152617.
DR GeneID; 106152617; -.
DR KEGG; lak:106152617; -.
DR InParanoid; A0A1S3H6H9; -.
DR OrthoDB; 5403296at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 95..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..317
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 429..675
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 751..782
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 809 AA; 95278 MW; 2DEF3DA1793357F4 CRC64;
MADEDRLIQD TDSTRNRRPS NTEFDEFYES GGIIPENPSS SERELNSVRQ QKVLWQYNYQ
EAAIFLEEGI NNDKFKTHPR TFDALPAYAL AHNKWYYLMD LLASLLLLGL IFCESPAVPF
LKLPIGAHAS LELFGLALLS VELGLKLRWQ GVKTFFSHKR TLFKTLLLFL MFTEAIVVLS
RQSNHFRVTR ALRPLFLLDS HYARGVRRFV RQILQSLPPI LDMIALLLFF MLIFSILGFY
LFSTNPDDPF FKTIQSSFIS LFVLLTTANY PDVMMPSYAQ SKWSCLFFVV YLSIELYFLM
SLLLAVVYDT FNTIEKTKLK KLYMHKRKAC EYAFKLLVTK KHPDKIRLKA FVGFMKYYKP
RKTPKEVYLI FKYLNKSSTG SLTSEEFHDI YNVCELQWKP RHQANQLWSS NFHYPFNKLF
KYLNALVTSR WFDYAIYVII AVNFVWILVE TIQISVDTTV SAREYRPSWN NILFVCVYSL
EAFLKILGLG VVKYFTNGWN IFDFLVTVSS VVGVFGEFYD DSFYYIMVLR PFRLLRLFKI
KRRYRDVLGT MMILSNRMVS LAIVMLLSFY FFSVIGMEIF APYTDKMVNC CKNTSVADYY
TKTNSSDGFY YLNNFENVMS SAVTLFELTV VNNWFIIMEG YASVVSEWSR IYFMLFYLSM
MVVMNIVVAF ILEAFIFRIQ YRKNVDDDMD DHAVVKLEVT LHPEEVVMVD SRGGHLSDYY
MRNAVFEQHV QEGHGTVFRG ERIRSKEDFS IKMYEDEVKE WIAEETEQRQ QYELQMQEMR
RQSQQNGLQI MQPDLIADDH YERSRTSTY
//