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Database: UniProt
Entry: A0A1S3H6V5_LINUN
LinkDB: A0A1S3H6V5_LINUN
Original site: A0A1S3H6V5_LINUN 
ID   A0A1S3H6V5_LINUN        Unreviewed;      2808 AA.
AC   A0A1S3H6V5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X2 {ECO:0000313|RefSeq:XP_013381712.1};
GN   Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381712.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381712.1};
RN   [1] {ECO:0000313|RefSeq:XP_013381712.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26383154;
RA   Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M.,
RA   Khalturina M., Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT   "The Lingula genome provides insights into brachiopod evolution and
RT   the origin of phosphate biomineralization.";
RL   Nat. Commun. 6:8301-8301(2015).
RN   [2] {ECO:0000313|RefSeq:XP_013381712.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2018) to UniProtKB.
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DR   RefSeq; XP_013381712.1; XM_013526258.1.
DR   GeneID; 106152615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013381712.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2248   2271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2306   2328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2377   2404       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2431   2452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2464   2485       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2497   2527       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    350       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      365    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2639   2659       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2808 AA;  323624 MW;  3305035285361D02 CRC64;
     MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
     QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
     IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
     DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
     SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
     ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
     DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
     SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
     QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
     YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
     LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
     HDKVSFDAKT CHIHLTGADV YLIERGQYIH KEHNVVYIST DAGHTWVPLH QFANADSPYY
     SEEEYLYLDR QLDLLGKLCK GRNQFSIRVI TKDLDILTWE NTFVCLRSEL LPPSLRAKYC
     SLIIDLFVDV GASHSVLDQH TLVFVYEDID NPRPLYSTKS QVATNVLFLA QELGTVFPVM
     RDWIQEFVES NPEMYSSQVG QNKLIEQVMR LLCYLVRFGC YCSADEIRIL LKPLMIMLDG
     RNDRPFPKNA EIQNSKEVKK LVKQYRETDR FEKSAETKAL VDAKYQGLSV LELLFTFQSN
     TRLESFVSKF KTAETTANAK KKKHRSVLSP LVDDSYDAFN TSKKNLRKQK KFLHELRAMF
     ESSSYFDVEY ITNISLDLSN YKYEKMLTQS LNILNKYYSS KTDMFKIAIP TLVLTTQESC
     KIHIDIMRQL PLVRHLAKCS YNMEQAEAMS VVFDQFVLFT HLRDEPTLRH PMNQKILINH
     GVLDLIFAIL SQEVDVQITE QAAPMELVFG KALNLLRFLA QGNEDVQAKM NDRLDSLMNI
     KLVPSHLAIA LREVFAGNQN NCLKIQPKQI LKIVHLAGEN QDRAPEFLDL LGSIVKVELL
     ELPLKRNQGL VMKYLMQNYH KAAYLFDQSQ EDRLRILTSK TGNSHQRYLI SLVDLLAKCA
     EGENRYIESL CQTIMPIEEI MDVLNNHFID NNLKSPYLRY LMWVYMKTAG TMIESGAGDL
     PHDRHVWIYI QALAREAESL KTYISENEVK TVEVMRAPPP KGAVAEMDDS DGAAHATLFY
     FFDAVLPFLQ TFFTKFYSPD KELYPDELEY VDQLAHSLVL WCDRVGAVLC NATHLKVLIG
     CVPSVLQSSS IPKNLSTESA LTNYPSLKPK QVQLWKNTYK VMEGFIEQYG NGRCLRDPTR
     ETIDTYTIYY QNEDELNKKF RAFSVNCSLV YGGHNTVTAQ LKHKSKREYT EIGGDEDLPL
     GEEFQAHVRC FVKHNEKNIA KRYQNVSKLV QQLAVSANAV NPKDGTYEND ELDIKSLQIL
     RAVIHNEERK LREDWEENTQ DKKVQKQLKV ILEVQNTLNS YSAVEEVLPH LGRPSNAIVR
     ESLAFLSIML FNANRNVQKA MLEYFMSTKK ESFFFAIRCR LQLSAIAIKE RRALATQHEA
     RVKESMTQAK SLQTNLTVGR KAMKDIQAIE RSRRQSRLMK GARANSLRAL QRDRQSGLTS
     ISPASSKCNS LQRFKLPNGS LNEETPLVFG SNHNDIELNE VMVEGSDNLS VDVEEDDVLD
     GLEFKDEGYI VLVLRLLAAM CDGQNQSIQD YLRDQPDNIK SINVVADTAQ FVNVVYSNIT
     ASTIDLVIQL FSTLNEFTAG NQANRVVLLD NKVVDYINFI LRAGKYEGIS MEMQLELREV
     IANLLVSLIE ENGPEPIKVA REVKDTVDKE AVYRCMVDCY SIHQPPTYKA KISTNMGDNM
     KNLSQMGGGL LREIMEKNKK NDLKDKAYEV GFLYFLLMAR FYDIDPVLNE KAGLVITPDQ
     MAAYNYYKKN SMSIELMKDG NLQKVHFRVK NKNVLREEVK EKLKWDVDRS SPSNKIRDLM
     AWSKDILKDI YYQRKMLRNP IAVFFTKFWL LWNYLVILLS VAINVLMLWA WKAPYDMSQA
     PENMTHLDHA IYNPNPDTSS VEIYDLLLYA MGGTHNLFSL FVLISYFLSN HPKCPSLSAI
     PNLCRRLCGR KDEEEDEIAH EVDCEKAKRQ SKLDVKFFSL ATFYYVIFVG MSVAGTFFHG
     YFFAFHLLNI VNNNQILQGV IKAVTQNGVS LLWVGILGVI IFYIYALISF AFMRALFLPK
     DEEYCGTLLE CSVTVIRYGL IGAIFDRLTL PESENNFIAF AVVAVFHLSF FILITTIGLN
     VILGIVVDTF SELRDLKWTA ESDMRDTCFI CSRGSHDFEH HGNGFLKHAR EEHNMWAYIF
     FFIHLDDTKS NDYTALDLHV AQALQREQYE FFPMNCALSL TGEEDGTDEK IDAVLEKVTE
     LLRRQREEES KRMREEEHRR QKQWQEMYRK ALSGSHDTLA AAIEGPRRPE DREGDAARYS
     DDDDSRGGVR TPETITLRDS ATSTEESPPR ESPRRTEEPP ETPRELLPPP PPPPSDGPHD
     VPPERPHDEP HALDMAPHVS EVAFPLTAPE DFPSPTFSDD DDFDDTRL
//
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