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Database: UniProt
Entry: A0A1S3H6W1_LINUN
LinkDB: A0A1S3H6W1_LINUN
Original site: A0A1S3H6W1_LINUN 
ID   A0A1S3H6W1_LINUN        Unreviewed;      2794 AA.
AC   A0A1S3H6W1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X6 {ECO:0000313|RefSeq:XP_013381717.1};
GN   Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381717.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381717.1};
RN   [1] {ECO:0000313|RefSeq:XP_013381717.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26383154;
RA   Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M.,
RA   Khalturina M., Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT   "The Lingula genome provides insights into brachiopod evolution and
RT   the origin of phosphate biomineralization.";
RL   Nat. Commun. 6:8301-8301(2015).
RN   [2] {ECO:0000313|RefSeq:XP_013381717.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2018) to UniProtKB.
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DR   RefSeq; XP_013381717.1; XM_013526263.1.
DR   GeneID; 106152615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013381717.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2234   2257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2292   2314       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2363   2390       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2417   2438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2450   2471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2483   2513       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    350       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      365    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2625   2645       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2794 AA;  322117 MW;  EB8AA7C7EA4B4EFD CRC64;
     MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
     QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
     IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
     DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
     SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
     ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
     DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
     SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
     QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
     YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
     LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
     HDKADVYLIE RGQYIHKEHN VVYISTDAGH TWVPLHQFAN ADSPYYSEEE YLYLDRQLDL
     LGKLCKGRNQ FSIRVITKDL DILTWENTFV CLRSELLPPS LRAKYCSLII DLFVDVGASH
     SVLDQHTLVF VYEDIDNPRP LYSTKSQVAT NVLFLAQELG TVFPVMRDWI QEFVESNPEM
     YSSQVGQNKL IEQVMRLLCY LVRFGCYCSA DEIRILLKPL MIMLDGRNDR PFPKNAEIQN
     SKEVKKLVKQ YRETDRFEKS AETKALVDAK YQGLSVLELL FTFQSNTRLE SFVSKFKTAE
     TTANAKKKKH RSVLSPLVDD SYDAFNTSKK NLRKQKKFLH ELRAMFESSS YFDVEYITNI
     SLDLSNYKYE KMLTQSLNIL NKYYSSKTDM FKIAIPTLVL TTQESCKIHI DIMRQLPLVR
     HLAKCSYNME QAEAMSVVFD QFVLFTHLRD EPTLRHPMNQ KILINHGVLD LIFAILSQEV
     DVQITEQAAP MELVFGKALN LLRFLAQGNE DVQAKMNDRL DSLMNIKLVP SHLAIALREV
     FAGNQNNCLK IQPKQILKIV HLAGENQDRA PEFLDLLGSI VKVELLELPL KRNQGLVMKY
     LMQNYHKAAY LFDQSQEDRL RILTSKTGNS HQRYLISLVD LLAKCAEGEN RYIESLCQTI
     MPIEEIMDVL NNHFIDNNLK SPYLRYLMWV YMKTAGTMIE SGAGDLPHDR HVWIYIQALA
     REAESLKTYI SENEVKTVEV MRAPPPKGAV AEMDDSDGAA HATLFYFFDA VLPFLQTFFT
     KFYSPDKELY PDELEYVDQL AHSLVLWCDR VGAVLCNATH LKVLIGCVPS VLQSSSIPKN
     LSTESALTNY PSLKPKQVQL WKNTYKVMEG FIEQYGNGRC LRDPTRETID TYTIYYQNED
     ELNKKFRAFS VNCSLVYGGH NTVTAQLKHK SKREYTEIGG DEDLPLGEEF QAHVRCFVKH
     NEKNIAKRYQ NVSKLVQQLA VSANAVNPKD GTYENDELDI KSLQILRAVI HNEERKLRED
     WEENTQDKKV QKQLKVILEV QNTLNSYSAV EEVLPHLGRP SNAIVRESLA FLSIMLFNAN
     RNVQRTMLDV FKSMRTETFF FAIRIRLEIA ANGLKERRAL ATQHEARVKE SMTQAKSLQT
     NLTVGRKAMK DIQAIERSRR QSRLMKGARA NSLRALQRDR QSGLTSISPA SSKCNSLQRF
     KLPNGSLNEE TPLVFGSNHN DIELNEVMVE GSDNLSVDVE EDDVLDGLEF KDEGYIVLVL
     RLLAAMCDGQ NQSIQDYLRD QPDNIKSINV VADTAQFVNV VYSNITASTI DLVIQLFSTL
     NEFTAGNQAN RVVLLDNKVV DYINFILRAG KYEGISMEMQ LELREVIANL LVSLIEENGP
     EPIKVAREVK DTVDKEAVYR CMVDCYSIHQ PPTYKAKIST NMGDNMKNLS QMGGGLLREI
     MEKNKKNDLK DKAYEVGFLY FLLMARFYDI DPVLNEKAGL VITPDQMAAY NYYKKNSMSI
     ELMKDGNLQK VHFRVKNKNV LREEVKEKLK WDVDRSSPSN KIRDLMAWSK DILKDIYYQR
     KMLRNPIAVF FTKFWLLWNY LVILLSVAIN VLMLWAWKAP YDMSQAPENM THLDHAIYNP
     NPDTSSVEIY DLLLYAMGGT HNLFSLFVLI SYFLSNHPKC PSLSAIPNLC RRLCGRKDEE
     EDEIAHEVDC EKAKRQSKLD VKFFSLATFY YVIFVGMSVA GTFFHGYFFA FHLLNIVNNN
     QILQGVIKAV TQNGVSLLWV GILGVIIFYI YALISFAFMR ALFLPKDEEY CGTLLECSVT
     VIRYGLIGAI FDRLTLPESE NNFIAFAVVA VFHLSFFILI TTIGLNVILG IVVDTFSELR
     DLKWTAESDM RDTCFICSRG SHDFEHHGNG FLKHAREEHN MWAYIFFFIH LDDTKSNDYT
     ALDLHVAQAL QREQYEFFPM NCALSLTGEE DGTDEKIDAV LEKVTELLRR QREEESKRMR
     EEEHRRQKQW QEMYRKALSG SHDTLAAAIE GPRRPEDREG DAARYSDDDD SRGGVRTPET
     ITLRDSATST EESPPRESPR RTEEPPETPR ELLPPPPPPP SDGPHDVPPE RPHDEPHALD
     MAPHVSEVAF PLTAPEDFPS PTFSDDDDFD DTRL
//
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