ID A0A1S3H821_LINUN Unreviewed; 895 AA.
AC A0A1S3H821;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|RefSeq:XP_013382265.1};
GN Name=LOC106153044 {ECO:0000313|RefSeq:XP_013382265.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013382265.1};
RN [1] {ECO:0000313|RefSeq:XP_013382265.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013382265.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013382265.1; XM_013526811.1.
DR AlphaFoldDB; A0A1S3H821; -.
DR EnsemblMetazoa; XM_013526811.1; XP_013382265.1; LOC106153044.
DR GeneID; 106153044; -.
DR KEGG; lak:106153044; -.
DR InParanoid; A0A1S3H821; -.
DR OrthoDB; 2970339at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF46; METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_013382265.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010168105"
FT TRANSMEM 566..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 574..838
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 27..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 99752 MW; 7D1CB1743D05FCD5 CRC64;
MNALFSLCIH TVMIFITVSF AAEKSDKKEH TETTQSPAFH GFSNKDTASE KDPRNPVPGH
VSGRVYRNTV VKNASETNND DVKGGSWTVY PEDDSPYVSY NATATEVGNY QPLWLQPDHV
HHGVSDTPAK SKKGRPVKVL YIGGFFELSG DPRMAAMGLS EKVAALMAID HINEQDILPG
YELRMFYGDT KCDPGTGADA FYDMVYTEQL MMLFGSSCSD VTSMIGQIVE YWNLLFVSHA
SSAPALSDRE TFPTFYRLAA ADVSHNAAQK KFIQHFNWNT VAIIHEDHEQ YNLAVHTLQS
TIEAANIKVA LTTSFRIQDS NLPDKMRQIK DNDIRIIIGS FSEDIAYHVF CEAYRQQIYG
LKYVWLLVGD FTSQWWEKSH NFSDCTEQEL TEAVNGYFAV NSLNFIVGNS KSTSGLTNEK
FEAQYDQKAK ELNARVTRSA HAPQMYDTVW TIALTLQAAA NASGGLENFR YENGTVWKSL
FFDIMGKLTF QGVSGPVSFT DTGDRRGISA FTRCQNGVMT SVALYYPNND TLSLNCKECK
PLLWTDGRPP ADKYSVVIQR SLIDPVAFYT ISALCGAGIF LALVFLFFNL LNLRRRYIKL
SSPKLNNVAV IGCILVYSAV LLLGFDDGTL SSKLYPTVCT VRAFLFAAGF SLAFGAMFTK
TYRVHQICIG AGTGLVKNKL LKDKHLFFII GALLVFDSAI VSLWALADPM VRNEKNITTE
PAPEDPHRIL YVRQHLHCHS QQQNIWLGVF YTYKGLLMIF GTFLAWSTRK VKIEALNDSR
YIGLSVYNVV VMSILVVALT AVIPDQPTLA YCIASSIIIV STTVTLCLLF VPKIHALVKS
SGNPVITTSG LTVEAETRRL TCDDSKEKLF RAEVQNKTFK SELAEVGALW IQFSD
//
