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Database: UniProt
Entry: A0A1S3H8A9_LINUN
LinkDB: A0A1S3H8A9_LINUN
Original site: A0A1S3H8A9_LINUN 
ID   A0A1S3H8A9_LINUN        Unreviewed;      2777 AA.
AC   A0A1S3H8A9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X10 {ECO:0000313|RefSeq:XP_013381721.1};
GN   Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381721.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381721.1};
RN   [1] {ECO:0000313|RefSeq:XP_013381721.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26383154;
RA   Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M.,
RA   Khalturina M., Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT   "The Lingula genome provides insights into brachiopod evolution and
RT   the origin of phosphate biomineralization.";
RL   Nat. Commun. 6:8301-8301(2015).
RN   [2] {ECO:0000313|RefSeq:XP_013381721.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2018) to UniProtKB.
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DR   RefSeq; XP_013381721.1; XM_013526267.1.
DR   GeneID; 106152615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013381721.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2217   2240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2275   2297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2346   2373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2400   2421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2433   2454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2466   2496       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    350       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      365    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2608   2628       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2777 AA;  320249 MW;  2D736BDA3493A2EB CRC64;
     MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
     QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
     IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
     DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
     SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
     ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
     DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
     SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
     QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
     YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
     LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
     HDKVSFDAKT CHIHLTGADV YLIERGQYIH KEHNVVYIST DAGHTWVPLH QFANADSPYY
     SEEEYLYLDR QLDLLGKLCK GRNQFSIRVI TKDLDILTWE NTFVCLRSEL LPPSLRAKYC
     SLIIDLFVDV GASHSVLDQH TLVFVYEDID NPRPLYSTKS QVATNVLFLA QELGTVFPVM
     RDWIQEFVES NPEMYSSQVG QNKLIEQVMR LLCYLVRFGC YCSADEIRIL LKPLMIMLDG
     RNDRPFPKNA EIQNSKEVKK LVKQYRETDR FEKSAETKAL VDAKYQGLSV LELLFTFQSN
     TRLESFVSKF KTAETTANAK KKKHRSVLSP LVDDSYDAFN TSKKNLRKQK KFLHELRAMF
     ESSSYFDVEY ITNISLDLSN YKYEKMLTQS LNILNKYYSS KTDMFKIAIP TLVLTTQESC
     KIHIDIMRQL PLVRHLAKCS YNMEQAEAMS VVFDQFVLFT HLRDEPTLRH PMNQKILINH
     GVLDLIFAIL SQEVDVQITE QAAPMELVFG KALNLLRFLA QGNEDVQAKM NDRLDSLMNI
     KLVPSHLAIA LREVFAGNQN NCLKIQPKQI LKIVHLAGEN QDRAPEFLDL LGSIVKVELL
     ELPLKRNQGL VMKYLMQNYH KAAYLFDQSQ EDRLRILTSK TGNSHQRYLI SLVDLLAKCA
     EGENRYIESL CQTIMPIEEI MDVLNNHFID NNLKSPYLRY LMWVYMKTAG TMIESGAGDL
     PHDRHVWIYI QALAREAESL KTYISENEVK TVEVMRAPPP KGAVAEMDDS DGAAHATLFY
     FFDAVLPFLQ TFFTKFYSPD KELYPDELEY VDQLAHSLVL WCDRVGAVLC NATHLKVLIG
     CVPSVLQSSS IPKNLSTESA LTNYPSLKPK QVQLWKNTYK VMEGFIEQYG NGRCLRDPTR
     ETIDTYTIYY QNEDELNKKF RAFSVNCSLV YGGHNTVTAQ LKHKSKREYT EIGGDEDLPL
     GEEFQAHVRC FVKHNEKNIA KRYQNVSKLV QQLAVSANAV NPKDGTYEND ELDIKSLQIL
     RAVIHNEERK LREDWEENTQ DKKVQKQLKV ILEVQNTLNS YSAVEEVLPH LGRPSNAIVR
     ESLAFLSIML FNANRNVQRT MLDVFKSMRT ETFFFAIRIR LEIAANGLKE RRALATQHEA
     RVKESMTQAK SLQTNLTVGR KAMKDIQAIE RSRRQSRLMK GARANSLRAL QRDRQSGLTS
     ISPASSKCNS LQRFKLPNGS LNEETPLVFG SNHNDIELNE VMVEGSDNLS VDVEEDDVLD
     GLEFKDEGYI VLVLRLLAAM CDGQNQSIQD YLRDQPDNIK SINVVADTAQ FVNVVYSNIT
     ASTIDLVIQL FSTLNEFTAG NQANRVVLLD NKVVDYINFI LRAGKYEGIS MEMQLELREV
     IANLLVSLIE ENGPEPIKVA REVKDTVDKE AVYRCMVDCY SIHQEKNKKN DLKDKAYEVG
     FLYFLLMARF YDIDPVLNEK AGLVITPDQM AAYNYYKKNS MSIELMKDGN LQKVHFRVKN
     KNVLREEVKE KLKWDVDRSS PSNKIRDLMA WSKDILKDIY YQRKMLRNPI AVFFTKFWLL
     WNYLVILLSV AINVLMLWAW KAPYDMSQAP ENMTHLDHAI YNPNPDTSSV EIYDLLLYAM
     GGTHNLFSLF VLISYFLSNH PKCPSLSAIP NLCRRLCGRK DEEEDEIAHE VDCEKAKRQS
     KLDVKFFSLA TFYYVIFVGM SVAGTFFHGY FFAFHLLNIV NNNQILQGVI KAVTQNGVSL
     LWVGILGVII FYIYALISFA FMRALFLPKD EEYCGTLLEC SVTVIRYGLI GAIFDRLTLP
     ESENNFIAFA VVAVFHLSFF ILITTIGLNV ILGIVVDTFS ELRDLKWTAE SDMRDTCFIC
     SRGSHDFEHH GNGFLKHARE EHNMWAYIFF FIHLDDTKSN DYTALDLHVA QALQREQYEF
     FPMNCALSLT GEEDGTDEKI DAVLEKVTEL LRRQREEESK RMREEEHRRQ KQWQEMYRKA
     LSGSHDTLAA AIEGPRRPED REGDAARYSD DDDSRGGVRT PETITLRDSA TSTEESPPRE
     SPRRTEEPPE TPRELLPPPP PPPSDGPHDV PPERPHDEPH ALDMAPHVSE VAFPLTAPED
     FPSPTFSDDD DFDDTRL
//
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