ID A0A1S3H8A9_LINUN Unreviewed; 2777 AA.
AC A0A1S3H8A9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381721.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381721.1};
RN [1] {ECO:0000313|RefSeq:XP_013381721.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_013381721.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR RefSeq; XP_013381721.1; XM_013526267.1.
DR EnsemblMetazoa; XM_013526267.1; XP_013381721.1; LOC106152615.
DR GeneID; 106152615; -.
DR OrthoDB; 5403784at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF100; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 2.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2217..2240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2275..2297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2346..2373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2400..2421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2433..2454
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2466..2496
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 113..167
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 2650..2777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2652..2678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2693..2711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2712..2728
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2729..2744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2777 AA; 320249 MW; 2D736BDA3493A2EB CRC64;
MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
HDKVSFDAKT CHIHLTGADV YLIERGQYIH KEHNVVYIST DAGHTWVPLH QFANADSPYY
SEEEYLYLDR QLDLLGKLCK GRNQFSIRVI TKDLDILTWE NTFVCLRSEL LPPSLRAKYC
SLIIDLFVDV GASHSVLDQH TLVFVYEDID NPRPLYSTKS QVATNVLFLA QELGTVFPVM
RDWIQEFVES NPEMYSSQVG QNKLIEQVMR LLCYLVRFGC YCSADEIRIL LKPLMIMLDG
RNDRPFPKNA EIQNSKEVKK LVKQYRETDR FEKSAETKAL VDAKYQGLSV LELLFTFQSN
TRLESFVSKF KTAETTANAK KKKHRSVLSP LVDDSYDAFN TSKKNLRKQK KFLHELRAMF
ESSSYFDVEY ITNISLDLSN YKYEKMLTQS LNILNKYYSS KTDMFKIAIP TLVLTTQESC
KIHIDIMRQL PLVRHLAKCS YNMEQAEAMS VVFDQFVLFT HLRDEPTLRH PMNQKILINH
GVLDLIFAIL SQEVDVQITE QAAPMELVFG KALNLLRFLA QGNEDVQAKM NDRLDSLMNI
KLVPSHLAIA LREVFAGNQN NCLKIQPKQI LKIVHLAGEN QDRAPEFLDL LGSIVKVELL
ELPLKRNQGL VMKYLMQNYH KAAYLFDQSQ EDRLRILTSK TGNSHQRYLI SLVDLLAKCA
EGENRYIESL CQTIMPIEEI MDVLNNHFID NNLKSPYLRY LMWVYMKTAG TMIESGAGDL
PHDRHVWIYI QALAREAESL KTYISENEVK TVEVMRAPPP KGAVAEMDDS DGAAHATLFY
FFDAVLPFLQ TFFTKFYSPD KELYPDELEY VDQLAHSLVL WCDRVGAVLC NATHLKVLIG
CVPSVLQSSS IPKNLSTESA LTNYPSLKPK QVQLWKNTYK VMEGFIEQYG NGRCLRDPTR
ETIDTYTIYY QNEDELNKKF RAFSVNCSLV YGGHNTVTAQ LKHKSKREYT EIGGDEDLPL
GEEFQAHVRC FVKHNEKNIA KRYQNVSKLV QQLAVSANAV NPKDGTYEND ELDIKSLQIL
RAVIHNEERK LREDWEENTQ DKKVQKQLKV ILEVQNTLNS YSAVEEVLPH LGRPSNAIVR
ESLAFLSIML FNANRNVQRT MLDVFKSMRT ETFFFAIRIR LEIAANGLKE RRALATQHEA
RVKESMTQAK SLQTNLTVGR KAMKDIQAIE RSRRQSRLMK GARANSLRAL QRDRQSGLTS
ISPASSKCNS LQRFKLPNGS LNEETPLVFG SNHNDIELNE VMVEGSDNLS VDVEEDDVLD
GLEFKDEGYI VLVLRLLAAM CDGQNQSIQD YLRDQPDNIK SINVVADTAQ FVNVVYSNIT
ASTIDLVIQL FSTLNEFTAG NQANRVVLLD NKVVDYINFI LRAGKYEGIS MEMQLELREV
IANLLVSLIE ENGPEPIKVA REVKDTVDKE AVYRCMVDCY SIHQEKNKKN DLKDKAYEVG
FLYFLLMARF YDIDPVLNEK AGLVITPDQM AAYNYYKKNS MSIELMKDGN LQKVHFRVKN
KNVLREEVKE KLKWDVDRSS PSNKIRDLMA WSKDILKDIY YQRKMLRNPI AVFFTKFWLL
WNYLVILLSV AINVLMLWAW KAPYDMSQAP ENMTHLDHAI YNPNPDTSSV EIYDLLLYAM
GGTHNLFSLF VLISYFLSNH PKCPSLSAIP NLCRRLCGRK DEEEDEIAHE VDCEKAKRQS
KLDVKFFSLA TFYYVIFVGM SVAGTFFHGY FFAFHLLNIV NNNQILQGVI KAVTQNGVSL
LWVGILGVII FYIYALISFA FMRALFLPKD EEYCGTLLEC SVTVIRYGLI GAIFDRLTLP
ESENNFIAFA VVAVFHLSFF ILITTIGLNV ILGIVVDTFS ELRDLKWTAE SDMRDTCFIC
SRGSHDFEHH GNGFLKHARE EHNMWAYIFF FIHLDDTKSN DYTALDLHVA QALQREQYEF
FPMNCALSLT GEEDGTDEKI DAVLEKVTEL LRRQREEESK RMREEEHRRQ KQWQEMYRKA
LSGSHDTLAA AIEGPRRPED REGDAARYSD DDDSRGGVRT PETITLRDSA TSTEESPPRE
SPRRTEEPPE TPRELLPPPP PPPSDGPHDV PPERPHDEPH ALDMAPHVSE VAFPLTAPED
FPSPTFSDDD DFDDTRL
//
