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Database: UniProt
Entry: A0A1S3H9A8_LINUN
LinkDB: A0A1S3H9A8_LINUN
Original site: A0A1S3H9A8_LINUN 
ID   A0A1S3H9A8_LINUN        Unreviewed;      2801 AA.
AC   A0A1S3H9A8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 3 isoform X3 {ECO:0000313|RefSeq:XP_013381714.1};
GN   Name=LOC106152615 {ECO:0000313|RefSeq:XP_013381714.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013381714.1};
RN   [1] {ECO:0000313|RefSeq:XP_013381714.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26383154;
RA   Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M.,
RA   Khalturina M., Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT   "The Lingula genome provides insights into brachiopod evolution and
RT   the origin of phosphate biomineralization.";
RL   Nat. Commun. 6:8301-8301(2015).
RN   [2] {ECO:0000313|RefSeq:XP_013381714.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2018) to UniProtKB.
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DR   RefSeq; XP_013381714.1; XM_013526260.1.
DR   GeneID; 106152615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000085678; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000085678};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013381714.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2241   2264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2299   2321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2370   2397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2424   2445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2457   2478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2490   2520       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    298       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      304    350       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      365    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2632   2652       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2801 AA;  322883 MW;  B61DE62177C36045 CRC64;
     MGEFLCIGDY ISLFCEETEG YVYSYQTSSS HNGLYIYQGQ DRKKPGKIPN PHAITFRVCI
     QNRYKLNKKY RKLLAASSKD PENLELKALV AQAKTSANAE NQDNISEQKR QHGKRVRYGE
     IIQLKHVFTD KYVHISTTQT SHRDKNNMLI SLHQYNGKHA QFRILPRYKV KSEGEYVQIL
     DQIVYESFKS QGHYFHSSVP WNIEKDMVGS ELNLGVAQTG FTVVRYYRPS DENEANVRGS
     SFIRLFHKEL EAYLVAEGLF GEPVQEEVHL RIREIDQLNP RTLSPPNSAI TYWQVEPEDT
     ILNGGVVRWE QQVRLRHVTT RRFLCLDADF EVCLTAEEND PRSVFRFHPV LSLREQDLDP
     DTPEQNEIDF ESYCRIEHVL TGNWLHALKD EPYQRRRDMG RENDRSMQAL RWDGGEVRKI
     SSTENRRYVD VFTIHEVEWE QIYSANFVAG MVPFLSKLIE SREECDYLNA MKTHQITTAL
     QELKQFMIIN GETYKDHQKL MRNFRIVDLL VQLLQSPLQD APDSNYLLSV FKEAYDILYT
     YMTGNSRKNA LYFAKYIEFF QTQLSLKAST SVMIKQYHLV VVDPTLKGDI GLNVAQMLVE
     LIRDNRQIVD RITHEQIDIF VDLLRQRKNY RFLDLLNVLC VCDGKTILEN QSYITETWLR
     HDKVSFDAKT CHIHLTGADV YLIERGQYIH KEHNVVYIST DAGHTWVPLH QFANADSPYY
     SEEEYLYLDR QLDLLGKLCK GRNQFSIRVI TKDLDILTWE NTFVCLRSEL LPPSLRAKYC
     SLIIDLFVDV GASHSVLDQH TLVFVYEDID NPRPLYSTKS QLAQELGTVF PVMRDWIQEF
     VESNPEMYSS QVGQNKLIEQ VMRLLCYLVR FGCYCSADEI RILLKPLMIM LDGRNDRPFP
     KNAEIQNSKE VKKLVKQYRE TDRFEKSAET KALVDAKYQG LSVLELLFTF QSNTRLESFV
     SKFKTAETTA NAKKKKHRSV LSPLVDDSYD AFNTSKKNLR KQKKFLHELR AMFESSSYFD
     VEYITNISLD LSNYKYEKML TQSLNILNKY YSSKTDMFKI AIPTLVLTTQ ESCKIHIDIM
     RQLPLVRHLA KCSYNMEQAE AMSVVFDQFV LFTHLRDEPT LRHPMNQKIL INHGVLDLIF
     AILSQEVDVQ ITEQAAPMEL VFGKALNLLR FLAQGNEDVQ AKMNDRLDSL MNIKLVPSHL
     AIALREVFAG NQNNCLKIQP KQILKIVHLA GENQDRAPEF LDLLGSIVKV ELLELPLKRN
     QGLVMKYLMQ NYHKAAYLFD QSQEDRLRIL TSKTGNSHQR YLISLVDLLA KCAEGENRYI
     ESLCQTIMPI EEIMDVLNNH FIDNNLKSPY LRYLMWVYMK TAGTMIESGA GDLPHDRHVW
     IYIQALAREA ESLKTYISEN EVKTVEVMRA PPPKGAVAEM DDSDGAAHAT LFYFFDAVLP
     FLQTFFTKFY SPDKELYPDE LEYVDQLAHS LVLWCDRVGA VLCNATHLKV LIGCVPSVLQ
     SSSIPKNLST ESALTNYPSL KPKQVQLWKN TYKVMEGFIE QYGNGRCLRD PTRETIDTYT
     IYYQNEDELN KKFRAFSVNC SLVYGGHNTV TAQLKHKSKR EYTEIGGDED LPLGEEFQAH
     VRCFVKHNEK NIAKRYQNVS KLVQQLAVSA NAVNPKDGTY ENDELDIKSL QILRAVIHNE
     ERKLREDWEE NTQDKKVQKQ LKVILEVQNT LNSYSAVEEV LPHLGRPSNA IVRESLAFLS
     IMLFNANRNV QRTMLDVFKS MRTETFFFAI RIRLEIAANG LKERRALATQ HEARVKESMT
     QAKSLQTNLT VGRKAMKDIQ AIERSRRQSR LMKGARANSL RALQRDRQSG LTSISPASSK
     CNSLQRFKLP NGSLNEETPL VFGSNHNDIE LNEVMVEGSD NLSVDVEEDD VLDGLEFKDE
     GYIVLVLRLL AAMCDGQNQS IQDYLRDQPD NIKSINVVAD TAQFVNVVYS NITASTIDLV
     IQLFSTLNEF TAGNQANRVV LLDNKVVDYI NFILRAGKYE GISMEMQLEL REVIANLLVS
     LIEENGPEPI KVAREVKDTV DKEAVYRCMV DCYSIHQPPT YKAKISTNMG DNMKNLSQMG
     GGLLREIMEK NKKNDLKDKA YEVGFLYFLL MARFYDIDPV LNEKAGLVIT PDQMAAYNYY
     KKNSMSIELM KDGNLQKVHF RVKNKNVLRE EVKEKLKWDV DRSSPSNKIR DLMAWSKDIL
     KDIYYQRKML RNPIAVFFTK FWLLWNYLVI LLSVAINVLM LWAWKAPYDM SQAPENMTHL
     DHAIYNPNPD TSSVEIYDLL LYAMGGTHNL FSLFVLISYF LSNHPKCPSL SAIPNLCRRL
     CGRKDEEEDE IAHEVDCEKA KRQSKLDVKF FSLATFYYVI FVGMSVAGTF FHGYFFAFHL
     LNIVNNNQIL QGVIKAVTQN GVSLLWVGIL GVIIFYIYAL ISFAFMRALF LPKDEEYCGT
     LLECSVTVIR YGLIGAIFDR LTLPESENNF IAFAVVAVFH LSFFILITTI GLNVILGIVV
     DTFSELRDLK WTAESDMRDT CFICSRGSHD FEHHGNGFLK HAREEHNMWA YIFFFIHLDD
     TKSNDYTALD LHVAQALQRE QYEFFPMNCA LSLTGEEDGT DEKIDAVLEK VTELLRRQRE
     EESKRMREEE HRRQKQWQEM YRKALSGSHD TLAAAIEGPR RPEDREGDAA RYSDDDDSRG
     GVRTPETITL RDSATSTEES PPRESPRRTE EPPETPRELL PPPPPPPSDG PHDVPPERPH
     DEPHALDMAP HVSEVAFPLT APEDFPSPTF SDDDDFDDTR L
//
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