ID A0A1S3HEM9_LINUN Unreviewed; 551 AA.
AC A0A1S3HEM9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Eukaryotic translation initiation factor 2D {ECO:0000313|RefSeq:XP_013384518.1};
GN Name=LOC106154648 {ECO:0000313|RefSeq:XP_013384518.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013384518.1};
RN [1] {ECO:0000313|RefSeq:XP_013384518.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013384518.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eIF2D family.
CC {ECO:0000256|ARBA:ARBA00010359}.
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DR RefSeq; XP_013384518.1; XM_013529064.1.
DR AlphaFoldDB; A0A1S3HEM9; -.
DR STRING; 7574.A0A1S3HEM9; -.
DR EnsemblMetazoa; XM_013529064.1; XP_013384518.1; LOC106154648.
DR GeneID; 106154648; -.
DR KEGG; lak:106154648; -.
DR InParanoid; A0A1S3HEM9; -.
DR OrthoDB; 102595at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:InterPro.
DR CDD; cd11608; eIF2D_C; 1.
DR CDD; cd21156; PUA_eIF2d-like; 1.
DR Gene3D; 3.10.400.20; -; 1.
DR Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR InterPro; IPR039757; EIF2D.
DR InterPro; IPR039759; eIF2D_SUI1.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR048248; PUA_eIF2d-like.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR PANTHER; PTHR12217; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR PANTHER; PTHR12217:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; eIF1-like; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS50890; PUA; 1.
DR PROSITE; PS50296; SUI1; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|RefSeq:XP_013384518.1};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_013384518.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 351..433
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT DOMAIN 457..530
FT /note="SUI1"
FT /evidence="ECO:0000259|PROSITE:PS50296"
FT REGION 129..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 61055 MW; 4B3F636EB1F742A6 CRC64;
MRVNFFIFFQ ELFVLFVVYT LWKNPDIVPV FTTWPPVFEK ISGGADLMLP GIVVKGDVTP
RSLWSLEKGA TCAINLAGNR CPVAIGRAAL SSSDMVDSGM RGKGVIVIHS YLDHLWAAGD
KGQLPIVHDG LAPSENFEEN GEAEEMSEEN SETFGEKSES AGIINTDNSL SDLTENQLSI
EKSDCAAGER DDNGLNSGVE NSNNRETEDV TVEESNIECQ EETISPEAMD DLLDICFMCA
LKTQVKKSDL PLLTSKFFRS YMVPFCPSGR FLDIKKSSHK KLSKFLQIKQ SQGLIDVKDL
SKGVESIVTI HKDNQSLREF SVPEGFAFHE EVQDEETSGA KASYQPPEIT LKYSVPHNLE
ILFKPSGYKK DSILVAGEVR KALVKYVSDN DLQDKDNKGR VVLDPILTDC LVSKNDYVTH
LRWNDLTSSC LSRMHAVHQI TFPGQKPVFK KGGIQPIKIN VAQRAGNKKV TLLENLETYG
IDPHEFAHTV QIDVACSTTV SPLPGKNKGM QVLVQGNQVA HVEKLLTEKY QIPQKFVSGL
EKAPKSGKKK R
//
