ID A0A1S3HF49_LINUN Unreviewed; 875 AA.
AC A0A1S3HF49;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Rho GTPase-activating protein 27 isoform X6 {ECO:0000313|RefSeq:XP_013384121.1};
GN Name=LOC106154344 {ECO:0000313|RefSeq:XP_013384121.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013384121.1};
RN [1] {ECO:0000313|RefSeq:XP_013384121.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013384121.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013384121.1; XM_013528667.1.
DR AlphaFoldDB; A0A1S3HF49; -.
DR EnsemblMetazoa; XM_013528667.1; XP_013384121.1; LOC106154344.
DR GeneID; 106154344; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 6.10.140.2130; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..73
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 250..284
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 363..396
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 452..563
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 679..874
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 109..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 99571 MW; C2B221DF82E60CB8 CRC64;
MATGRGSHTY VLVLYDYDYV ADDGSPVSIK KDEEYVLLKK ANKDWWHVAN LHAKANGEKP
FYVPAAYVEE IYKNVISVGP GEIRETNEDV QMDATVTVNE DQVTTIKVGY DQEPEPDYPG
DPPDLHPKTP KPNEDLDNNN MKDFSFQEDS DSVRVKQSPQ IVRQKSAPPE VPQKPQRRYE
DPTYANLEEV RVAAGMDRPL SQVSQSSDLS QDSPDSDRDY ANYRPGSLSP FSTFAISPPS
PSLVPNNPKK NLDYGWEEHL DETTGRTYYY NVHTRQTSWN PPRVRARIRS HSDAVFTARQ
RLQLNTSRDS AFSSDFSPAS PVSPHSPSIS PLRPSTLSSK SASLPRGWKQ EVNDGGEVTF
VNDGLGEKWL CSQDDQGRTY YYKEDGSESA WELPEMPKLD YERQFSNDSQ PDEREFSADL
DPTDQHGGSG GARRPSAPVG PGEVSQSPRQ RPPEKRGYLK VTKIMDGNKK LKKNWSQIFI
VLTGPKLFFY KDTKSAVGQQ GKPDQEFEVG KMDVEWAGKE VSSKKNTIQL SCTVDLELQQ
YLLQQDDQGV MQEWHSDISK AIKRFRPRPA ESLQHSTSFK KSATLPATLQ SNESYDSVQM
RPISARGRFQ SSSKSRKSEL VRMASSKYIV TPDQETVDQM NFSDKKSKIR DRLLKFLKKR
PTMESLQEQG ILQESVFGSH LDRLCERERT TVPIFVKRCI QAIENKGLSI DGIYRVSGNL
AQVQKLRCAV DQGIMSLLDQ EGEYNFFESE WDIHVLTGSL KLFFRELQEP VFPFAVFDRL
IAAIKGDPSK RIPMLRDIVK TLPRPNYDTL KVLFEHLNRV IGRSNENRMQ VQNIAIVFGP
TLMWPEKESH NMAISMMFQS NIVEVMLTEY QNIFR
//
