ID A0A1S3HH87_LINUN Unreviewed; 687 AA.
AC A0A1S3HH87;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=LOC106154868 {ECO:0000313|RefSeq:XP_013384851.1,
GN ECO:0000313|RefSeq:XP_013384852.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013384851.1};
RN [1] {ECO:0000313|RefSeq:XP_013384851.1, ECO:0000313|RefSeq:XP_013384852.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013384851.1,
RC ECO:0000313|RefSeq:XP_013384852.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR RefSeq; XP_013384851.1; XM_013529397.1.
DR RefSeq; XP_013384852.1; XM_013529398.1.
DR EnsemblMetazoa; XM_013529397.1; XP_013384851.1; LOC106154868.
DR EnsemblMetazoa; XM_013529398.1; XP_013384852.1; LOC106154868.
DR GeneID; 106154868; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 2.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 687 AA; 77977 MW; D6A9838515E25530 CRC64;
MEKPSMGDKI KRKLSLPKMV GLEDENKVRG NWSGRLDFFL SCIGYAVGLG NIWRFPYICY
RNGGGAFLIP YCIFLLLCGM PLVFLEIAYG QFCSQSPTGV WKLSPMFKGI GWGMVIVSGI
VCIYYNIIIT WTLYYLLMSF QAVLPWSHCN NDWNDENCAL WHKRSPNATN HTHQGPLDPL
LDGAGVVRLM GNLTANSSAS YWMHYGVDGT NSTNVTIQRE SPSEQYWQNH VLELSEGIEN
IGPIRWQLLL CLIFAWVMIF LCLCKGVKSS GKVVYVTATF PYLVLIILLV RGVTLPGSME
GIKYYLIPKW EKLLSFKVWA EAAGQIFYSV GAAWGAMITF ASYNRFQNNC LRDAIIVPLL
NEGTSIFAGF VIFSIIGFMA QETGRTVDAV ITQGPGLAFV VYPGALAKLP ISPMWAVLFF
LMLLTVGVDS QFGMFETMTS AFVDEYPHFL RKRKTLFIAA TCFVQFLLGI VIVTKGGIYI
LQIMDWYSST YSLMVFSFME CIVVAYVYGV DRFYEDIELM IGRKPPILYK YSWLFVTPAV
ILFIFVATFF QHESVTYGDY HYPAWAIVLG WLLALCSILP IPGIMILKIV REKGPILQRI
KKLCRPAVDW GPVPTKFREQ YYESLSPARR QWLREFHPEM KFTVNQLEDE GIMMKPLKPN
DSLHDKPASV PHEEKALIQG QQECNNV
//
