ID A0A1S3HNM1_LINUN Unreviewed; 803 AA.
AC A0A1S3HNM1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X5 {ECO:0000313|RefSeq:XP_013387636.1, ECO:0000313|RefSeq:XP_023930185.1};
GN Name=LOC106156763 {ECO:0000313|RefSeq:XP_013387636.1,
GN ECO:0000313|RefSeq:XP_023930185.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013387636.1};
RN [1] {ECO:0000313|RefSeq:XP_013387636.1, ECO:0000313|RefSeq:XP_023930185.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013387636.1,
RC ECO:0000313|RefSeq:XP_023930185.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013387635.1; XM_013532181.1.
DR RefSeq; XP_013387636.1; XM_013532182.2.
DR RefSeq; XP_013387637.1; XM_013532183.1.
DR RefSeq; XP_023930185.1; XM_024074417.1.
DR EnsemblMetazoa; XM_013532182.2; XP_013387636.1; LOC106156763.
DR EnsemblMetazoa; XM_024074417.1; XP_023930185.1; LOC106156763.
DR GeneID; 106156763; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20830; C1_PIK3R-like_rpt2; 1.
DR CDD; cd12923; iSH2_PI3K_IA_R; 1.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF5; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..55
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 83..133
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 154..349
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 397..493
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 675..790
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 353..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 579..620
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 359..374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 92963 MW; AB257D63C35692DD CRC64;
MAALNLYRYV ELFKRNNIKG KDLMTLDESK LEVMGILDDF HRKAILVCID DLCGRESEQQ
PHGSALPPSN EPLDVAVNCV DTDHKVVEYS FSSLQRCHIC NKFLHGLMHQ GLQCRECGLC
CHRTCAKTGL ICCSPEIMEK RRRISFVANF VFGADLTDQF NPSDQQAPDV IVHCTQEIER
RGKDTGEDLF DVYRISSSTQ AIQELKAVLN SEDISGLNTA HFDLNCIAGA LKKYLRELPN
SVIPVEYYSQ FIEAAKNKDD EQCKERLVQL ASDLPPHHSS TLRYLMAHFV HLCQHQYALG
KREPPVKLSH VFCHILMRPP WEKIIDIVYN TEYHIRVFDC LLRGGNWGET MPDYTETTAD
VPPPRPPRPP KLHQQPPQDQ NTENNNPSQD PLEEAEWYWG EISREEVNEK LKDTPDGTFL
VRNATTWSRD GDYTLTLRKG GSNKLIKIYH KNGKYGFVEP LKFSSVQELV AHYRQHTLGQ
YNKTLDVTLK YPLSKHQQAE DADLNANLDE VCKRLVEINR EYLKKTLKYD KLYDGHSRTT
QELQLKHQAL DAFSETITVF EDQITLHDKF KQQAQPHELQ KLEENYKLLA DRLQEIKRSK
EQLEEDLRYQ TEENRRLIEE MNSLKPEIKR EYKLREQYIK YLIDKNVNKD YIDEKLLGET
ERRISQGTPD EEEPYYVGAP VMNNDLPSIA HYNESTWYID CDRYTAENLL QNKPDGTFLI
RPSSKMNSYA LSLNANGRTG HCVIEHKATG FGFAEPFFIH QTLLDLVLHY RETSLHEHNP
ELDVTLVHPV KAPQPGSSYT YMQ
//
