ID A0A1S3HQ91_LINUN Unreviewed; 622 AA.
AC A0A1S3HQ91;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like isoform X2 {ECO:0000313|RefSeq:XP_013388223.1};
GN Name=LOC106157195 {ECO:0000313|RefSeq:XP_013388223.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013388223.1};
RN [1] {ECO:0000313|RefSeq:XP_013388223.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013388223.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013388223.1; XM_013532769.1.
DR AlphaFoldDB; A0A1S3HQ91; -.
DR EnsemblMetazoa; XM_013532769.1; XP_013388223.1; LOC106157195.
DR GeneID; 106157195; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR PANTHER; PTHR46026:SF1; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..66
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 92..272
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 293..397
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 396..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 568..606
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 622 AA; 69775 MW; CFC4EF176FA99760 CRC64;
MAEVISPQPK IVVGAYNFKG TNNDELCFCK GDLITVTQIV DGGWWEGTLN GQTGWFPANY
VKEVKLDPKT GLPPGVKAGE IKLNKRESTA HYQSVVLQNI IDQEQAHVTE LQELLEKYLK
PLQEAGILSG AEYSQLCGNL EDITVFQENF LAQLKEIAKM PSNQQKVGGS FMMNAPQLIS
LYKTYCSNHP QAVSVLQTHR EKLDQFMENQ GAVAPGVITL TTSLSNPFRM LDRYPVLLKE
LERHIEDCHV DRGDTQRAIA VFRDIASSCT EIRKQKELEL DIFSSTISGL EDSISQYGDV
LLLSQVLMHM EGGEKAERLF ILFPGKLIIL SANPQQEGYT FESKITLSGT TAKAIEDEDS
VLNAFEISGN TTDKIVVSCA SPHEQKAWLD ALRQQNKPKA PPALSTPPSH SHSHTIPAKL
TPLQLSTSQP NINVTATLPA QGKKFKMTPQ PLFKAHKTWS LSCLRPCPPL RPVYFSRDDP
TKSPRSGRKF RTLTRRPVDD AKTMEDALIL KVIEAYCTSA KTRHTVNSSL LDSPHMLIAE
EEKIIFEEQK GDQTVVEEKT LVDTVYAIKD QLKELREEQV LLRKELEEER RARKRIEAML
NKSRRSLRSL VDGPWEESSP IL
//
