ID   A0A1S3HRR8_LINUN        Unreviewed;       864 AA.
AC   A0A1S3HRR8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Protein IWS1 homolog {ECO:0000313|RefSeq:XP_013388241.1};
GN   Name=LOC106157209 {ECO:0000313|RefSeq:XP_013388241.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013388241.1};
RN   [1] {ECO:0000313|RefSeq:XP_013388241.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013388241.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family.
CC       {ECO:0000256|ARBA:ARBA00037992}.
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DR   RefSeq; XP_013388241.1; XM_013532787.2.
DR   AlphaFoldDB; A0A1S3HRR8; -.
DR   STRING; 7574.A0A1S3HRR8; -.
DR   EnsemblMetazoa; XM_013532787.2; XP_013388241.1; LOC106157209.
DR   GeneID; 106157209; -.
DR   KEGG; lak:106157209; -.
DR   InParanoid; A0A1S3HRR8; -.
DR   OrthoDB; 12240at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR   PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT   DOMAIN          660..738
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51319"
FT   REGION          1..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          746..864
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..57
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..117
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..146
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..496
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..535
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..785
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        812..849
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        850..864
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  94641 MW;  8C4260F1D5472E91 CRC64;
     MSSGEEDGGG TPLQDEPEYG YQLEEAQPPG GTQPFSIGRS HFEDEEEEEE GEIADEEENE
     LPAHRRESYT GEDQEEDSEG QLSGEEADDG DVQQRDEESM EDQGSDDDGE IQDSDNDNAN
     MDESNQYPQP EEEEDGDGEI DSPMAEEQEG ADIRSPSPEG SQEGEEVRSP SPMSDQSDDD
     QGPASPAGSD HQSPGGEESQ GPASPSQGSA HSPSEDGGDR MDNMEVQNQD SQQSSRMSDF
     ESGETTGDNQ KNSEYDSAQD SQLDSVAWSE TMVEENRSEY VPNQPPFSTH SAVVSEGPQS
     PSAQGNWSSV DSYQGPQSPS NSNQGPQSPS NSDQGPQSPD DGSRGPISPS NSNQGPQSPS
     FQDEVSQDSV NKDGPTSPSS SNQGPQSPPG FQGDAAEGPA SPVEKPEEGP ASPSSDAEGP
     RSPSNKDEES RDGSEAERRR GEDEEAKAGS GDEGKKSEAG SEDEKDTKEE RHNVSLDKEG
     SEKGSDEEDS DKESNVGELI ADIFGSSDEE EEFEGFQDAD METPKKKKVA VISDDEGENE
     APAEGEGDAS AALPQLSDDD EGVEDGDKGN FVSDFDLMLE RKKEEMRKRR RKRKDFDIIN
     DNDDLIAALI NQMKTAAEED RALNNQSKPA IKKLRMLPEV LQQLRKSDLQ GAFLDCGILP
     ALTEWLAPLP DKSLPHLQIR EGLLRILQGF PPISSEALKS SGLGKAVMYL YKHPREIREN
     HERAGKLINE WSRPIFNLTS NYKNLSKEER EQRDYEQLPK KRRISSEGGK TPRRDIDKAL
     AGDQKALRPG DKGWVQRARV PMPSNKDYVV RPHSNLDSDA PRKSSGKKDM SRLEKHMRNF
     QERKKQNKSQ RAVGISIEGR NMSL
//