ID A0A1S3HS51_LINUN Unreviewed; 665 AA.
AC A0A1S3HS51;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=LOC106156982 {ECO:0000313|RefSeq:XP_013387884.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013387884.1};
RN [1] {ECO:0000313|RefSeq:XP_013387884.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013387884.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR RefSeq; XP_013387884.1; XM_013532430.1.
DR AlphaFoldDB; A0A1S3HS51; -.
DR EnsemblMetazoa; XM_013532430.1; XP_013387884.1; LOC106156982.
DR GeneID; 106156982; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 665 AA; 74791 MW; BA1C74640E7854FF CRC64;
MKPRKAVVCS KRVAIVAQII NDPTYTHRED DNNYIGDVSM DHLERMVWSR KLEFILSCLG
YAVGLGNLWR FPYMCYRNGG GAFFIPYLIM LLFCGFPLFY LEISLGQFAS LGPLSVWKVS
PLFKGVGYGI VTVSLMVSIY YNMIIGWSIF YLFASMQDPV PWSTCDNWWN TAACTMDGRQ
HQNASNNSTI ILNSVMGNIS LNDSADVGDT IVSLDPYENV TQNLTYVGRL KSSSEEYFYN
YVLGITDDIS DFGGMQWYNV GCLCLAWLLV FLALRKGIKT SGKVVYFTAI FPYVVLVILL
IRGVSLDGAV EGIKFFLIPK WERLRQAKVW NDAAIQVFYS LGSCFGTLIT LASYNKFHNN
CYKDAVIVCV GNTLTSVLGG VVIFSILGYM AHVSGTTVDK VAQEGSGLAF VVYPEVVAKF
PVSPLWAILF FIMLLTLGLD SQFGMIETLV TAILEEYPKQ CHKRKTWVIL GVCIVMFILG
LPLCTKGGMY WLHLMDLNAA GWSVLILGLF ECLVIGWVYG YNRFADNIQM MIGKKPSLYW
RALWQFVTPV IIMFILVFSW VDYSPAYYDQ YEYPFWANLL GGAMTCLPLV PLPVWMLYAI
SKTDGPIKRR IQLLTQPAAD WGPGPSIDED IVAFLVPQHP LLPPALHLHP DLPETPVWGD
RQQGL
//
