ID A0A1S3I190_LINUN Unreviewed; 774 AA.
AC A0A1S3I190;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=GATOR2 complex protein WDR24 {ECO:0000256|ARBA:ARBA00040269};
GN Name=LOC106160059 {ECO:0000313|RefSeq:XP_013392028.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013392028.1};
RN [1] {ECO:0000313|RefSeq:XP_013392028.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013392028.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat WDR24 family.
CC {ECO:0000256|ARBA:ARBA00008134}.
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DR RefSeq; XP_013392028.1; XM_013536574.1.
DR AlphaFoldDB; A0A1S3I190; -.
DR STRING; 7574.A0A1S3I190; -.
DR EnsemblMetazoa; XM_013536574.1; XP_013392028.1; LOC106160059.
DR GeneID; 106160059; -.
DR KEGG; lak:106160059; -.
DR InParanoid; A0A1S3I190; -.
DR OrthoDB; 119005at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:InterPro.
DR CDD; cd16693; mRING-H2-C3H3C2_WDR24; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR037590; WDR24.
DR InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR PANTHER; PTHR46200; GATOR COMPLEX PROTEIN WDR24; 1.
DR PANTHER; PTHR46200:SF1; GATOR COMPLEX PROTEIN WDR24; 1.
DR Pfam; PF00400; WD40; 4.
DR Pfam; PF17120; zf-RING_16; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 96..138
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 183..218
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 723..772
FT /note="WDR59/RTC1-like RING zinc finger"
FT /evidence="ECO:0000259|Pfam:PF17120"
FT REGION 475..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 86724 MW; 50D7796413E5392F CRC64;
MHTVIEAPIN AISTNKDASQ VVVAGRNVFR VFSIEDDAFV ERCNLRVGKN LNLNFSAADV
TWNPVEDHLL ASAATNGAVV TWNLNKPSRS KQELVFNEHK RTVNRVCFHS TEANLLLSGS
QDGFMKLFDL RKKEVNCTFS GQSESVRDVQ FCPHHYFQFA AAYENGNLQL WDLRRPDKWE
KMFTAHSGPA FTLDWHPDDK NWIASAGRDR SIKIWEISHK PRLLHTVQTI ASVARVKWRP
SRKYHISSCS LLVDHNVNVW DIRRPYIPFA SFEEHRDVVT GIMWKNDPYV FLSGSKDCTV
YQHMFKDAVR PADRANPIGI DTNVNGDLGL AFSDKLLVAG KSQTGSSMLP HFFRSKGPDR
SEQFTMASSS AVIFESVDKS TGLEWFIECA TRYQLSGKSV EDLCDHNAAV AGSLNKHQVA
QTWRILKLLY GGNTATPCPP RTVSVIGSPA VGEAHKAESE KVNLKQQLDG HLVQDHNRST
HTDGENKDTG DTSTAVSEDE SDAESSLSLT NIASGQVNQQ GDFFFGDGEL ETFDYPVTMA
NMDSMQDWTL PTEAIPLRHE IQDRLDSPDP LQNATDSPSS ANESEFSSQA FGNAENATPM
YNLQAIPFAS QNPPWEFSHL VCDMLEYFAE QGDVQTSVSV LIILGNKMKT PVEDQKQEQW
FMAYLELLTR FRLWGIANEV IKLSSHRAVA SLNQQSTTVH TNCNKCFKPL TRAGWLCDRC
KALTSTCSIC HLPVKGLFAW CQGCSHGGHL EHLREWLMTH KHCPTGCGHI CEYT
//
