UniProt: A0A1S3I5S0

Database: UniProt
Entry: A0A1S3I5S0_LINUN

LinkDB:  A0A1S3I5S0_LINUN 
Original site:  A0A1S3I5S0_LINUN

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Ontology (3)   
   GO (3)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (11)   
   InterPro (8)   
   Pfam (2)   
   PROSITE (1)   
All databases (16)   

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ID   A0A1S3I5S0_LINUN        Unreviewed;       430 AA.
AC   A0A1S3I5S0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Glycine receptor subunit alpha-3 isoform X2 {ECO:0000313|RefSeq:XP_013392719.1};
GN   Name=LOC106160576 {ECO:0000313|RefSeq:XP_013392719.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013392719.1};
RN   [1] {ECO:0000313|RefSeq:XP_013392719.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013392719.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
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DR   RefSeq; XP_013392719.1; XM_013537265.1.
DR   AlphaFoldDB; A0A1S3I5S0; -.
DR   EnsemblMetazoa; XM_013537265.1; XP_013392719.1; LOC106160576.
DR   GeneID; 106160576; -.
DR   OrthoDB; 5393084at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18991; LGIC_ECD_GlyR; 1.
DR   CDD; cd19049; LGIC_TM_anion; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF898; GLUTAMATE-GATED CHLORIDE CHANNEL; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Receptor {ECO:0000313|RefSeq:XP_013392719.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           26..430
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022263762"
FT   TRANSMEM        257..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        323..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        409..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          55..256
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          264..351
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
SQ   SEQUENCE   430 AA;  49912 MW;  35C64FE28F079CA3 CRC64;
     MEMKRLLHFV HIAALLLLTM SPLEAAGGKK EKRKRRRENN VHHDPPAVNS TSWFLGKLLR
     NYDKLRPPMQ DKSTRVELGI YINSFYSISE QTMDFSVNIY LRQNWTDPRL AFDPQEGGRD
     MIKLEDGYWD RLWVPDVFFR NEKKANYHDV TIPNRLMRLY SNGQIWYVTK ISATLSCPMD
     LKKYPLDVQH CPMMLESFGY TMDVLYFVWM KNAVDMDDHV SLPQYKLQGH QLEDCSQNYT
     AGAFPCLKVT FNLKRDIGYY MIQVYVPTAL IVILSWVAFW ISIDSSPARV SLGLLTVLTM
     TTQSASARAS LPRVSYIKAL DVWMSVCLVF VFASLLEYAA VNVFSRREIP KPSKASSLME
     KFKGPSDKSL RSLTEVENGV NGRKQPPQYI RDPFGREKAR MVDKLSRKLF PTTFILFCLI
     YWPVYIFIDM
//

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