ID A0A1S3I5Z6_LINUN Unreviewed; 1257 AA.
AC A0A1S3I5Z6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Son of sevenless homolog 1-like isoform X1 {ECO:0000313|RefSeq:XP_013393700.1};
GN Name=LOC106161320 {ECO:0000313|RefSeq:XP_013393700.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013393700.1};
RN [1] {ECO:0000313|RefSeq:XP_013393700.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013393700.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|ARBA:ARBA00002001}.
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DR RefSeq; XP_013393700.1; XM_013538246.1.
DR AlphaFoldDB; A0A1S3I5Z6; -.
DR STRING; 7574.A0A1S3I5Z6; -.
DR EnsemblMetazoa; XM_013538246.1; XP_013393700.1; LOC106161320.
DR GeneID; 106161320; -.
DR KEGG; lak:106161320; -.
DR InParanoid; A0A1S3I5Z6; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 207..394
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 445..550
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 601..744
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 780..1019
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1017..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1065
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1180
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 143774 MW; 998FAE31D4A2A245 CRC64;
MSILSPIAVS GSEQSIYNFE SEDNSAKWKS LLVAALQKVQ HQVHPSLSCR EDALEYIETL
IFQLLGMLCS CQPHNVQEVE DRVQKTFPHP IDKWAVSDAQ NALEKGKKKS PLVLPVDKIH
PLLIREVLGY KVDFQVSLYV VAVLEYIAAD ILKLAGNYVK NIKHQEITCQ DIKVAMCADK
VLMDMFFQDD EVSLTVEEEP VRRDSLTYEE IVKDLVLEET QYLRELDMII KVFRAPFANL
FPKSKDLEVI FSNVLDIRNL TSKLLSSLED TVEMTDENTP PLIGGCFEEI AEGAEFEVYG
KYTEDMMKPH ARDRLNTLLQ RKDVSLTFQT AGQGFVEAVK YVLPKLLLGP IYHFLHYFES
IKALKDASID EEDKQSLEEA ESMLLPLKTE VEKKSAGLLA KRKPGESTFR LHGQLGRQAT
LHKINELQKQ IDGWEGKAIR QSCNEFVMEG VLLKQTGRNL RERQAFLFDG LIILCKQNLR
RSSVTIGPAV EFRLKEKFYM RKVDVIDHED AEDLKNAFEL QVRDHPSVTL VAKTYEEKCN
WMAALIALHT RSMLDRKLDS ILVEEEKNAP LRLPSKEEYR FGDEDTPENI VFEQNLKYEG
ESPLIKGGTL LKLVERLTYH MYRYADPKFV RTFLTTFRSF CTPQELLDLL IERFNIPEPL
PVDPVKELDD LAYREEIKRF RKEFVKPIQF RVLNVLRHWV NNHFYDFERD SDLQDKLKEF
LDTVKGKAMR KWVESITKII QRRQEIPGGE KPEVVLSVTP PQIEWYAART PDEYNLMTLH
PIEIARQVTL LEFDLYRAVK PSELVGSVWI KKEKNQTSPN LLKMIHHSTM FTFWLERCII
EADNFEERIA VMSRTLEILL VFQELNNFNG MLEVVSALHS APVYRLEHTF IELPHKLLKA
FDEAKELNSD HFKKYIEKLR SINPPCVPFL GMYLTNILYT EEGNPDFLVN RGPGLINFSK
RRKVAEICGE IQQYQNQPYC LIPEPSIRQF FENLNPLEDM TEKEFNDYLY NKSLELEPRH
AKGPTKHPRK NGYPLKSPGI KPSSGRDSVL KPSSIRDRHG TLPKSLHEGR AFSFARLQEE
DIDLPGSQCG TPSTPSTPLT PPAVSQGNVS DSDSSVFAQV LIGPGEGIQG NNEPPEVPPI
PPPLPPRRRD HSSSSEPPSS VPPVPPRPDQ PPPPLPPRRT TDPNMRTHSA YALQHFYHGD
IISHAGSTSS LFTRRNSDRE TSSSSSSSAF VNGDSEPNSV PALPPKTYKT LQRNQSS
//
