ID A0A1S3I674_LINUN Unreviewed; 1656 AA.
AC A0A1S3I674;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106161368 {ECO:0000313|RefSeq:XP_013393757.1,
GN ECO:0000313|RefSeq:XP_013393758.1, ECO:0000313|RefSeq:XP_013393760.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013393757.1};
RN [1] {ECO:0000313|RefSeq:XP_013393757.1, ECO:0000313|RefSeq:XP_013393758.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013393757.1,
RC ECO:0000313|RefSeq:XP_013393758.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR RefSeq; XP_013393757.1; XM_013538303.1.
DR RefSeq; XP_013393758.1; XM_013538304.1.
DR RefSeq; XP_013393760.1; XM_013538306.1.
DR STRING; 7574.A0A1S3I674; -.
DR EnsemblMetazoa; XM_013538303.1; XP_013393757.1; LOC106161368.
DR EnsemblMetazoa; XM_013538304.1; XP_013393758.1; LOC106161368.
DR EnsemblMetazoa; XM_013538306.1; XP_013393760.1; LOC106161368.
DR GeneID; 106161368; -.
DR KEGG; lak:106161368; -.
DR OrthoDB; 5403652at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00130; KR; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kringle {ECO:0000256|PROSITE-ProRule:PRU00121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_013393757.1,
KW ECO:0000313|RefSeq:XP_013393758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1656
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014545812"
FT TRANSMEM 981..1002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..158
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 398..502
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..608
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 612..709
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 713..824
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1095..1348
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1268..1339
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1380..1645
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1564..1636
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1394..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1656 AA; 187146 MW; 8D92E0B24879F0D3 CRC64;
MAERQNVRAL HIFGVFLVIL CIQGSAFANC PSGRYGWRCR YECQCQDGVE CDQTTGECVG
GCQDDRWGPG CILDSNCYYD DHDGIHYTGK KTLPNCVRWD SGSPIIYSNY RNASYFPDKT
LSDAANLCRN PSENPWNEGP WCYTESVSRY TSCSLRKCDC PAFRFGINCR SECHCSDEEE
DCSLTGICSS GCADGWKGGD CQTACPDGSF GPNCLKDCHC ANPTEACNKT TGKCSSGCKE
GWTGEDCHQT GCEDDRYGEN CQKACMCRNP AHCNKEAGPT EECQCIRGYY KPQGQLGCQP
VTPPRITYFE NEKANPGQSA KFTCIAFAKP APQEEEIHLM TPRGKTVVSS ESQLVTDTVR
ERSFVVDKVN PREVYRCNVS TEAGFSIQNT TAYSYELPTL NATPVVRVDN NKITLSWRKW
NEKDDQGDGP IVEYTVETAT HIKMDWRYEG DLNRCFQQCH YFMSKVQVFP NTRYFFRVIP
RREGEGGRGN PSPVAEYKTP CDAPSEAPIL GKLNSSYNNF DKTKITAIWK LPSPASYNCD
NVEKQIVYIS TSPMVNGEAV LLPGKQVSVH FFNRLVPYTK YYIRVQFENN AQLRSPVSNV
EAIITPEHTP GKPRNVNVSP KDGISLIVRW DAPEPPGGEI IQYQVAWWLY GATDQQRKNV
TINYPATRIR ETVLKDLHPH TKYGIGVRAK TIKGYGPWTD TKPHMTDETL PGPPYAIRNS
SRSNTLIVLA WQPPTYLGGT LRDYYVACIP HALTVSVQDE KGLIQRYLNV ERRSQEARVA
PQKNSAVVDN LSPGTKYRCS VNASTSKGFG PAISIDVWTY PKQPVAPSVP QIIKEETTDT
TISVNLQPAL DDVGLYRLVV ERLPKKSNRR RRSITVEELN TKVSLPDYFE AMKHNMSHYL
AAEFPARELR RPRRFVVGNG KKYGGYYNAP LEKGSEYSLW FGAGSSADGI TVFTYSKAGE
PMLAQVFVPP PKEAATGETT IGIAVAVIVI AILVAALVAA IFMRRRKRHQ SKELLNSSTE
TEKSPQDVKG ISIDMDSTQC TDSLLPNGEP PEYELASEPL YDNVTKDTTP IRQPIEVEKL
YDYVMAKRDS TTMGFKQEYE LLPSGFIAQH DVASKIENKH KNRYGNIIAY DHSRVVLEPY
EGDPLSDYIN ANYIDGYKDS KAYIATQGPS KVTLADWWRM IWQENVSTVV MVTNLVEGGR
AKCEQYWPRN DKTTYGEITV EVKQVEIIAD YTIRTFELNK GNESKVVKQF HFTTWPDHGV
PIFATSLLAF HRKVKAYHTP QLGPMVLHCS AGVGRSGTFI ALDYLLDQAK VEGVVDIFNT
VHLMRKQRVK MIQTLEQYIF LHDALLEALL SGNTGMFCTD MRHRYNNLLK VNPATGETEM
DAQFDLLNKL TSSIPREPEK TSGRDAKNAN KNRVPDMVPA NHARPHLMTP LENKEGTDYI
NAAFIDGFRK RDALIITQMP LQHTAVDFWR MIHDHMIFSI VMLNEMDSSD ESCVPYWPEQ
AEPQEYGPFK VEMVSSNMGI GMITRDFKLT HKRQSADKFR IIRQFQYTCW SKTDSVPQSM
PSLLALLSAV EKWQQQTRDR TIVVHCMDGA SQSGVFCAMY YIMDKIKTQQ ELDVYHTVNH
LRINRKQLIK NKEQYRFCYD FALAYLDSFE PYANFK
//
