ID A0A1S3I9Y7_LINUN Unreviewed; 721 AA.
AC A0A1S3I9Y7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN Name=LOC106161740 {ECO:0000313|RefSeq:XP_013394219.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013394219.1};
RN [1] {ECO:0000313|RefSeq:XP_013394219.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013394219.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013394219.1; XM_013538765.1.
DR AlphaFoldDB; A0A1S3I9Y7; -.
DR EnsemblMetazoa; XM_013538765.1; XP_013394219.1; LOC106161740.
DR GeneID; 106161740; -.
DR KEGG; lak:106161740; -.
DR InParanoid; A0A1S3I9Y7; -.
DR OrthoDB; 2960371at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 2.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR14453; PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14453:SF67; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR Pfam; PF01661; Macro; 2.
DR Pfam; PF00644; PARP; 1.
DR SMART; SM00506; A1pp; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52949; Macro domain-like; 2.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS51154; MACRO; 2.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50918; WWE; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 1..115
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 137..310
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT DOMAIN 430..511
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 519..721
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
SQ SEQUENCE 721 AA; 80894 MW; E5070B8DA92CBED0 CRC64;
MSTGEMKKTD GFNLQCQKIY HVVCPDWGPA KEQTLSRLMS QCLEQAHQDG VSSIAFPALG
TGNLKFPKDV VADVMFKEAL QFSAKNSQTK VKEIRFVLYP QDTQTITAFK MKLFEVQGRP
KTVHFRRRKG ITMQLEKPNF MELSCNAVTV QVKQGNVMED TVDIIVNTVD PQLNMGVLGK
HLVKAGGNDI KKELQTKKRH AQNGAVLDTT PGKLPFKRIY HVVIPPANQI HRSIQQCLLL
AEKFGFSSIA FPAIGTGKAN LDPANCAKET LSGIFQTLQE NNIESLKMIC VTVYDQGQIP
IFIDEARAQS TVTGRTRKGR RQSMRQRQSL TALQRVVLDV YGASDKVAET DEDIAAFIKQ
NIQKETIELK GHTITQADIA EIRDLEVERG VTATIDTNTS TISIVGCPVD VSPTVSTIYK
IIHKKIEDRA EEDKAAALQQ KIQWCWLAAK DQSREPFDKM TNYRVELAHR AREGSVVYEI
EGSPCKLDFS TMTETDCSND IVTQVIREVK DPSLPSHWSP QPRDSDIPHA VHQVNIKAGD
QEFNKVAEQF NAAFDTDGVR RKKIVQLLRI QNPHLYKQYK TYSAKLEREN QGMNNEMSLF
HGTSEANCDY ISHQGFNRSF GGLNVGAIFG KGVYFAKKAT YSAQPCYCKP NAAGEQFMFL
AKVLVGSYTK GHRKMLTPPP KDPDKPLETY NSVVDNTKTP TIFVIFYDAQ AYPEYLIKFK
A
//
