ID A0A1S3IBK7_LINUN Unreviewed; 823 AA.
AC A0A1S3IBK7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Echinoderm microtubule-associated protein-like 2 isoform X8 {ECO:0000313|RefSeq:XP_013395553.1, ECO:0000313|RefSeq:XP_013395554.1};
GN Name=LOC106162713 {ECO:0000313|RefSeq:XP_013395553.1,
GN ECO:0000313|RefSeq:XP_013395554.1, ECO:0000313|RefSeq:XP_013395555.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013395553.1};
RN [1] {ECO:0000313|RefSeq:XP_013395553.1, ECO:0000313|RefSeq:XP_013395554.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013395553.1,
RC ECO:0000313|RefSeq:XP_013395554.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR RefSeq; XP_013395553.1; XM_013540099.1.
DR RefSeq; XP_013395554.1; XM_013540100.1.
DR RefSeq; XP_013395555.1; XM_013540101.1.
DR EnsemblMetazoa; XM_013540099.1; XP_013395553.1; LOC106162713.
DR EnsemblMetazoa; XM_013540100.1; XP_013395554.1; LOC106162713.
DR EnsemblMetazoa; XM_013540101.1; XP_013395555.1; LOC106162713.
DR GeneID; 106162713; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR CDD; cd21931; TD_EMAP-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR049813; Elp-1-like_TD.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 176..245
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 463..495
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 547..588
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 599..689
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 676..717
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 788..823
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 51..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 90803 MW; F508A441564465BE CRC64;
MLDHENEELR ERVSALEKKV HQNEDEMLCL KSALADALRR IASLESGRTA GLTNNVLPSK
PFKPQPRRVS SAPVSAADSR SKRAGSVEQA FVTRDTAPPQ KRAPTPTPKA PPSPSPTSLK
KWSSLSSAEF QGGNLQMSRS FQSVTCLTDK TRATDRKAMA HRRKETTFNK EEGYLRMYLR
GRPVTLYAPT LEEYDLAKKE DQPPQSLKLE WVYGYRGRDC RSNVHLLPTG ETVYFVAGVV
VLYNVEEQIQ RHYLGHTDDV KCLAVHPDKI TIATGQVAGH DNKKSSRPKS AQHGKGDPST
APDHLPHVRV WNSVSLQTLH ILGLGGDFDR AVCSIGFSKA DGGQLLCAVD EGNEHTLSVW
EWQKGEKGHK ITETKSSTEP VVASEFHPLD ANTIITCGKN QITFWTLEGG TLGKKLGLFE
KHEKPKFVLC LAIADNGDVF TGDSNGNIFI WPRGTNKISK ALTGVHEGGI FSLLFTKDGH
LLSGGGKDRR IVQWDATGLT QTGEVEIPEH YGAVRTLTQG KGNMIVVGST RNVILQGTLE
LNFNPIVQGH VDELWGLAVH PNQHQFLTCA YDKKVFLWDA LSHSAVWSKE LEVPAHCACF
HPDAQVVAIG TQTAKWLVLD LTSREPVYSH TDGNEQIECA EYSPDGKYLA LGSRDNHIYV
YSVDEEGKKY SRVGKCQGHS SFVTHLDWSA DSQYIQSNSG DYELLFWNAS SCKQITASSS
MRDVQWATSY CTISFNTCGI WPEGADGTDV NGSSRAHKAD LLASADDYGK VNLYRYPSTH
IEAGHRAYGG HSSHVTAVRF LHDDSRLLST GGKDAGILQW EIL
//
