ID   A0A1S3ICG0_LINUN        Unreviewed;       860 AA.
AC   A0A1S3ICG0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Echinoderm microtubule-associated protein-like 2 isoform X2 {ECO:0000313|RefSeq:XP_013395546.1};
GN   Name=LOC106162713 {ECO:0000313|RefSeq:XP_013395546.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013395546.1};
RN   [1] {ECO:0000313|RefSeq:XP_013395546.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013395546.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC       {ECO:0000256|ARBA:ARBA00003210}.
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DR   RefSeq; XP_013395546.1; XM_013540092.1.
DR   AlphaFoldDB; A0A1S3ICG0; -.
DR   EnsemblMetazoa; XM_013540092.1; XP_013395546.1; LOC106162713.
DR   GeneID; 106162713; -.
DR   OrthoDB; 2959353at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   CDD; cd21931; TD_EMAP-like; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR049813; Elp-1-like_TD.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; WD40 repeat-like; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          213..282
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          500..532
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          584..625
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          636..726
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          713..754
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          825..860
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          89..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..152
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  95084 MW;  412B78B265C7763C CRC64;
     MIPICQYGFE VIQALLMEPI VDAKKESWKM VRFVLDGMLD HENEELRERV SALEKKVHQN
     EDEMLCLKSA LADALRRIAS LESGRTAGLT NNVLPSKPFK PQPRRVSSAP VSAADSRSKR
     AGSVEQAFVT RDTAPPQKRA PTPTPKAPPS PSPTSLKKWS SLSSAEFQGG NLQMSRSFQS
     VTCLTDKTRA TDRKAMAHRR KETTFNKEEG YLRMYLRGRP VTLYAPTLEE YDLAKKEDQP
     PQSLKLEWVY GYRGRDCRSN VHLLPTGETV YFVAGVVVLY NVEEQIQRHY LGHTDDVKCL
     AVHPDKITIA TGQVAGHDNK KSSRPKSAQH GKGDPSTAPD HLPHVRVWNS VSLQTLHILG
     LGGDFDRAVC SIGFSKADGG QLLCAVDEGN EHTLSVWEWQ KGEKGHKITE TKSSTEPVVA
     SEFHPLDANT IITCGKNQIT FWTLEGGTLG KKLGLFEKHE KPKFVLCLAI ADNGDVFTGD
     SNGNIFIWPR GTNKISKALT GVHEGGIFSL LFTKDGHLLS GGGKDRRIVQ WDATGLTQTG
     EVEIPEHYGA VRTLTQGKGN MIVVGSTRNV ILQGTLELNF NPIVQGHVDE LWGLAVHPNQ
     HQFLTCAYDK KVFLWDALSH SAVWSKELEV PAHCACFHPD AQVVAIGTQT AKWLVLDLTS
     REPVYSHTDG NEQIECAEYS PDGKYLALGS RDNHIYVYSV DEEGKKYSRV GKCQGHSSFV
     THLDWSADSQ YIQSNSGDYE LLFWNASSCK QITASSSMRD VQWATSYCTI SFNTCGIWPE
     GADGTDVNGS SRAHKADLLA SADDYGKVNL YRYPSTHIEA GHRAYGGHSS HVTAVRFLHD
     DSRLLSTGGK DAGILQWEIL
//