ID A0A1S3IDI1_LINUN Unreviewed; 558 AA.
AC A0A1S3IDI1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN Name=LOC106162685 {ECO:0000313|RefSeq:XP_013395494.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013395494.1};
RN [1] {ECO:0000313|RefSeq:XP_013395494.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013395494.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR RefSeq; XP_013395494.1; XM_013540040.1.
DR AlphaFoldDB; A0A1S3IDI1; -.
DR EnsemblMetazoa; XM_013540040.1; XP_013395494.1; LOC106162685.
DR GeneID; 106162685; -.
DR OrthoDB; 5393599at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF8; PROTEIN TWEETY; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 58..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 415..440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 458..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 61821 MW; 927854CFDD86AB91 CRC64;
MNSGRGAEHP GLTLGGEKTE YIPSWLAALF HSFPHISLKF RLSNSTFNLD DEEYIQSLGF
AAALPVLLLL LVLFIFSIYC CCRCSSCCNK NAASPRRKNT PCLKWTIAII TLLTCGVLAS
GLFGNEKFNK GVLQVRLAGS SAAETIDSAN DVVGDMGTTI NNSIVVGVNG FDALFKKSPV
PNATIGLMLD KDLQAMVQQG RNIMKYASEI HKDADTSQIR KILEDIKQYE GYRWLATIVV
LSFELLICLL LLIAVMTESK ALLMVCTAFV VFNLIISWLT AGVYLGVSVG AGDLCVDPDQ
FVSEEAKKSG FVDQAVVHYY ITNCTSLSDN PFRDDLQSAS ASVSKINSSL TDIVWLASPF
FEQYQIDQYS NPIRQDLKKL VGDLENLQSM VDCTPIHNDY VSALKGMCYK GLDGLAFMLL
SAAVTGFLLA FVIVFNSRAW RHWGKRLKRK GRYSSIDEDD PFLPNIDQDS DQTPVKYYRS
RGPYTNIEED DPFLPRLGPE QSRPTSPLLT EQTPSGQLRR ERLVLQNRDQ GSPPPAYEYY
ADHGRSRYAT GTASPTDV
//
