ID A0A1S3IE80_LINUN Unreviewed; 608 AA.
AC A0A1S3IE80;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Histone-lysine N-methyltransferase PRDM9-like {ECO:0000313|RefSeq:XP_013396565.1};
GN Name=LOC106163511 {ECO:0000313|RefSeq:XP_013396565.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013396565.1};
RN [1] {ECO:0000313|RefSeq:XP_013396565.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013396565.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_013396565.1; XM_013541111.1.
DR AlphaFoldDB; A0A1S3IE80; -.
DR STRING; 7574.A0A1S3IE80; -.
DR EnsemblMetazoa; XM_013541111.1; XP_013396565.1; LOC106163511.
DR GeneID; 106163511; -.
DR KEGG; lak:106163511; -.
DR InParanoid; A0A1S3IE80; -.
DR OrthoDB; 2960873at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19193; PR-SET_PRDM7_9; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044417; PRDM7_9_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR23235:SF149; LOW QUALITY PROTEIN: ZINC FINGER PROTEIN 239-RELATED; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13465; zf-H2C2_2; 2.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 240..352
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 381..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 412..439
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 440..467
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 468..490
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 496..523
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 524..551
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 552..579
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 580..603
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 69..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 70347 MW; E621EFF6203852A1 CRC64;
MASKFEIPKL PNVEQMDFSK MDMTDPDKVN IEAYFTASEL AKLSDYEKLR LRNIKRNYQV
LKDLGLPIAK PQFMKPKKKP AQKKKVKDES SGSDEEWTPE LDRRKSGRAL KSVERFQPPP
KPDRTVQRTK TKVNSMKDKE ENLKAIKTKK KSVSLGTNST SNIVHKGVHQ PRYPKRKAGD
KNYKDLEVPD DDAFLYCDEC NMEYAGDCPV HGPLNIVEDV QVPADGSDPE RARKTLPPYF
NIYTSQIPDA GLGVWVIRTL KNRTRFGPYE GEISTDTAKA HESGYSWQVY KEGQPSHFVD
AQDPSKANWM RYVNCARTER EQNLVAFQYH GQIYYKTIKP IPEGNELLVW YGDAYAMELG
IDKTKPESNL DLLRKLNVEV YECDICGKLF ADDEYLVKHR KRHPDMTGSK KYKCAFCNYS
TNSVAGHQNH LLTHTGERPH KCEVCGKGFS LEHDLIKHKR IHTGEKPYKC TVCGKRFNQL
SHLHTHQRIH DNSIVFTCTV CGKQCSQAGV LKRHMRIHTG EKPYKCQFCD KRFNRDFILK
RHMRIHTGEK PYKCQFCDKR FNQLPSLKGH MSVHTGEKPY KCQFCDRGFN FNCDMHKHIR
KVHPEDAC
//
