ID A0A1S3IH01_LINUN Unreviewed; 262 AA.
AC A0A1S3IH01;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN Name=LOC106163645 {ECO:0000313|RefSeq:XP_013396759.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013396759.1};
RN [1] {ECO:0000313|RefSeq:XP_013396759.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013396759.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Preautophagosomal structure membrane
CC {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004472}.
CC -!- SIMILARITY: Belongs to the ATG27 family.
CC {ECO:0000256|ARBA:ARBA00005363}.
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DR RefSeq; XP_013396759.1; XM_013541305.1.
DR AlphaFoldDB; A0A1S3IH01; -.
DR EnsemblMetazoa; XM_013541305.1; XP_013396759.1; LOC106163645.
DR GeneID; 106163645; -.
DR KEGG; lak:106163645; -.
DR InParanoid; A0A1S3IH01; -.
DR OrthoDB; 5477545at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR018939; Autophagy-rel_prot_27.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF38; AUTOPHAGY-RELATED PROTEIN 27; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF09451; ATG27; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..262
FT /note="Autophagy-related protein 27"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010189774"
FT TRANSMEM 196..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..182
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
SQ SEQUENCE 262 AA; 28044 MW; 85903C7BB089C8CD CRC64;
MASCNSVTTA GVVLVPYLLL LCFSGGATLK CTKTGPCSCS SSEGDIDLSP LANSDGSPRF
KDVAPTAPAD YAVYSWNPCT DFTEPVQSSN AVCNNIAVCQ IYGSGTSYTY GYSLGKQESA
TFTNDDAGQV VLTYTDTGSN RNAKFTLICD RNVDSKLDVI GEDQNNINVH TFKLTTKYAC
VGKSGPSGGG LSGGTILIII FILVAFLYFF LGMFVMVAYY KARGTDMIPN KNFWMGFPFL
VKDGCVFVFR GCKSGEGSYQ KV
//
