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Database: UniProt
Entry: A0A1S3IL06_LINUN
LinkDB: A0A1S3IL06_LINUN
Original site: A0A1S3IL06_LINUN 
ID   A0A1S3IL06_LINUN        Unreviewed;       599 AA.
AC   A0A1S3IL06;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 2.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   Name=LOC106164739 {ECO:0000313|RefSeq:XP_013398204.2};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013398204.2};
RN   [1] {ECO:0000313|RefSeq:XP_013398204.2}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_013398204.2};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   RefSeq; XP_013398204.2; XM_013542750.2.
DR   AlphaFoldDB; A0A1S3IL06; -.
DR   STRING; 7574.A0A1S3IL06; -.
DR   EnsemblMetazoa; XM_013542750.2; XP_013398204.2; LOC106164739.
DR   KEGG; lak:106164739; -.
DR   InParanoid; A0A1S3IL06; -.
DR   OrthoDB; 2898719at2759; -.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR   Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR038158; H-NOX_domain_sf.
DR   InterPro; IPR011644; Heme_NO-bd.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07700; HNOB; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT   DOMAIN          315..443
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          76..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..582
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|RefSeq:XP_013398204.2"
SQ   SEQUENCE   599 AA;  65992 MW;  555EF34E5F3ADD50 CRC64;
     CESNEDGTLT LHYISPRKGL YPIVIGVVKA VGRELFNIDC TIEVIDRLGE QTNTNNVGMA
     AQDHVIFRVT ENKNSLTTTT TTTTSKTTAA KETSTPNGAT NGTSVIAESK DFSPHFPDSL
     HIDPRNFCTA FPFHIIFDRE LCVLQSGTGI QRLCPEIRAA GSSLRENFVL EHPLINMTWD
     NIVMFINAVF VFSVKQTRMP LKGQIVLLNL DAMLFICSPR LTNLNELMDK QFYLSDIPIY
     DVTRELILLN QQREAEIEVS KKLDETTAEL KRTSLALERE KQRTEFLLHQ MLPKKVADQL
     KQGKSVDAEK FDEVTILFSD IVTFTNIAAA CQPIDIVHML NNLYAKFDAS TTKNNVYKVE
     TIGDAYMVVS GVPEVVKDHA ECVCDQALDM VTAASEVKSP ATGRALQIRV GMHSGPVVAG
     VVGLKMPRYC LFGDTVNTAS RMESHGIPGK IHLSPDTYRA LMRKGAACRY QFQPRGALNV
     KGKGVMHTHF LVGKDEKRPD LVVDESDAQY QRLDPEDTPS MKQTSEQSAA ASVKGGSGAN
     GNSDVTSVPV TQQSQLDVKE SIKTSQSQES SPNGCCSSND NCTVVREPIR GRSATCQLM
//
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