ID A0A1S3IL06_LINUN Unreviewed; 599 AA.
AC A0A1S3IL06;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 2.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=LOC106164739 {ECO:0000313|RefSeq:XP_013398204.2};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_013398204.2};
RN [1] {ECO:0000313|RefSeq:XP_013398204.2}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_013398204.2};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_013398204.2; XM_013542750.2.
DR AlphaFoldDB; A0A1S3IL06; -.
DR STRING; 7574.A0A1S3IL06; -.
DR EnsemblMetazoa; XM_013542750.2; XP_013398204.2; LOC106164739.
DR KEGG; lak:106164739; -.
DR InParanoid; A0A1S3IL06; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 315..443
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 76..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_013398204.2"
SQ SEQUENCE 599 AA; 65992 MW; 555EF34E5F3ADD50 CRC64;
CESNEDGTLT LHYISPRKGL YPIVIGVVKA VGRELFNIDC TIEVIDRLGE QTNTNNVGMA
AQDHVIFRVT ENKNSLTTTT TTTTSKTTAA KETSTPNGAT NGTSVIAESK DFSPHFPDSL
HIDPRNFCTA FPFHIIFDRE LCVLQSGTGI QRLCPEIRAA GSSLRENFVL EHPLINMTWD
NIVMFINAVF VFSVKQTRMP LKGQIVLLNL DAMLFICSPR LTNLNELMDK QFYLSDIPIY
DVTRELILLN QQREAEIEVS KKLDETTAEL KRTSLALERE KQRTEFLLHQ MLPKKVADQL
KQGKSVDAEK FDEVTILFSD IVTFTNIAAA CQPIDIVHML NNLYAKFDAS TTKNNVYKVE
TIGDAYMVVS GVPEVVKDHA ECVCDQALDM VTAASEVKSP ATGRALQIRV GMHSGPVVAG
VVGLKMPRYC LFGDTVNTAS RMESHGIPGK IHLSPDTYRA LMRKGAACRY QFQPRGALNV
KGKGVMHTHF LVGKDEKRPD LVVDESDAQY QRLDPEDTPS MKQTSEQSAA ASVKGGSGAN
GNSDVTSVPV TQQSQLDVKE SIKTSQSQES SPNGCCSSND NCTVVREPIR GRSATCQLM
//